Watermaze learning enhances excitability of CA1 pyramidal neurons

M. Matthew Oh, Amy G. Kuo, Wendy W. Wu, Evgeny A. Sametsky, John F. Disterhoft

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

The dorsal hippocampus is crucial for learning the hidden-platform location in the hippocampus-dependent, spatial watermaze task. We have previously demonstrated that the postburst afterhyperpolarization (AHP) of hippocampal pyramidal neurons is reduced after acquisition of the hippocampus-dependent, temporal trace eyeblink conditioning task. We report here that the AHP and one or more of its associated currents (IAHP and/or sIAHP) are reduced in dorsal hippocampal CA1 pyramidal neurons from rats that learned the watermaze task as compared with neurons from control rats. This reduction was a learning-induced phenomenon as the AHP of CA1 neurons from rats that failed to learn the hidden-platform location was similar to that of neurons from control rats. We propose that reduction of the AHP in pyramidal neurons in regions crucial for learning is a cellular mechanism of learning that is conserved across species and tasks.

Original languageEnglish (US)
Pages (from-to)2171-2179
Number of pages9
JournalJournal of neurophysiology
Volume90
Issue number4
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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    Oh, M. M., Kuo, A. G., Wu, W. W., Sametsky, E. A., & Disterhoft, J. F. (2003). Watermaze learning enhances excitability of CA1 pyramidal neurons. Journal of neurophysiology, 90(4), 2171-2179. https://doi.org/10.1152/jn.01177.2002