Voluntary weight reduction in older men increases hip bone loss: The osteoporotic fractures in men study

Kristine E. Ensrud, Robin L. Fullman, Elizabeth Barrett-Connor, Jane A. Cauley, Marcia L. Stefanick, Howard A. Fink, Cora E. Lewis, Eric Orwoll

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

To test the hypothesis that weight loss in older men is associated with increased rates of hip bone loss regardless of adiposity and intention to lose weight, we measured body weight, body composition, hip bone mineral density (BMD), and intention to lose weight in a cohort of 1342 older men enrolled in the Osteoporotic Fractures in Men (MrOS) study and followed them prospectively for an average of 1.8 yr for changes in weight and BMD. The adjusted average rate of change in total hip BMD was 0.1%/yr in men with weight gain, -0.3%/yr in men with stable weight, and -1.4%/yr in men with weight loss (test for trend, P <0.001). Higher rates of hip bone loss were observed in men with weight loss regardless of category of body mass index, body composition, or intention to lose weight. Even among obese (body mass indes, ≥30 kg/m2) men trying to lose weight, those with documented voluntary weight reduction experienced an increase in hip bone loss (average rate of change in total hip BMD, 0.5%/yr in those with weight gain, -0.1%/yr in those with stable weight, and -1.7%/yr in those with weight loss; test for trend, P <0.001). Older men who experience weight loss have increased rates of hip bone loss, even among overweight and obese men undergoing voluntary weight reduction.

Original languageEnglish (US)
Pages (from-to)1998-2004
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number4
DOIs
StatePublished - Apr 2005

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Pelvic Bones
Osteoporotic Fractures
Weight Loss
Bone
Weights and Measures
Minerals
Bone Density
Body Composition
Weight Gain
Chemical analysis
Adiposity
Body Mass Index
Body Weight

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Voluntary weight reduction in older men increases hip bone loss : The osteoporotic fractures in men study. / Ensrud, Kristine E.; Fullman, Robin L.; Barrett-Connor, Elizabeth; Cauley, Jane A.; Stefanick, Marcia L.; Fink, Howard A.; Lewis, Cora E.; Orwoll, Eric.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 4, 04.2005, p. 1998-2004.

Research output: Contribution to journalArticle

Ensrud, KE, Fullman, RL, Barrett-Connor, E, Cauley, JA, Stefanick, ML, Fink, HA, Lewis, CE & Orwoll, E 2005, 'Voluntary weight reduction in older men increases hip bone loss: The osteoporotic fractures in men study', Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 4, pp. 1998-2004. https://doi.org/10.1210/jc.2004-1805
Ensrud, Kristine E. ; Fullman, Robin L. ; Barrett-Connor, Elizabeth ; Cauley, Jane A. ; Stefanick, Marcia L. ; Fink, Howard A. ; Lewis, Cora E. ; Orwoll, Eric. / Voluntary weight reduction in older men increases hip bone loss : The osteoporotic fractures in men study. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 4. pp. 1998-2004.
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