Volumetric imaging of blood flow within cochlea in gerbil in vivo

Niloy Choudhury, Fangyi Chen, Xiaorui Shi, Alfred L. Nuttall, Ruikang K. Wang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Changes in blood flow to the inner ear are thought to influence a number of cochlear diseases, including noise-induced hearing loss, sudden hearing loss, and Menieres disease. Advances have been made in the areas of vital microscopic studies of microcirculation, and the laser Doppler flowmetry. But none of these techniques can provide in vivo 3-D mapping of microvascular perfusion within the cochlea. To overcome this limitation, we have developed and used a method of optical microangiography (OMAG) that can generate 3-D angiograms within millimeter of tissue depths by analyzing the endogenous optical scattering signal obtained from an illuminated sample. We used OMAG to visualize the cochlear microcirculation of adult living gerbil through the intact cochlea, which would be difficult, if not impossible, by use of any other current techniques.

Original languageEnglish (US)
Article number5299290
Pages (from-to)524-529
Number of pages6
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume16
Issue number3
DOIs
StatePublished - May 1 2010

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Keywords

  • Biomedical imaging
  • Cochlear blood flow
  • Optical coherence tomography
  • Optical microangiography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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