Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia

Jeffrey Kaye, T. Swihart, Diane Howieson, A. Dame, M. M. Moore, T. Karnos, R. Camicioli, M. Ball, Barry Oken, G. Sexton

Research output: Contribution to journalArticle

332 Citations (Scopus)

Abstract

Objective: To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and parahippocampus) in preclinical dementia. Background: Postmortem studies suggest that the earliest changes in Alzheimer's disease are neurofibrillary tangle formation in hippocampus and adjacent cortex. MRI volume analysis of temporal lobe structures over time in subjects prior to developing dementia may allow the identification of when these processes begin, the rate they develop, and which areas are key to symptom development. Methods: 30 nondemented (NoD), healthy, elderly individuals enrolled in a prospective study of healthy aging evaluated annually over a mean of 42 months. Twelve subjects with subsequent cognitive decline were assigned to the preclinical dementia group (PreD). All 120 annual MRI studies analyzed by volumetric techniques assessed group differences in temporal lobe volumes and rates of brain loss. Results: NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume. Rates of volume loss between the groups did not significantly differ. PreD cases had significantly smaller hippocampi when asymptomatic. Parahippocampal volume did not differ between PreD and NoD cases. Significant time-dependent temporal lobe atrophy was present only in PreD. Conclusions: Hippocampal and parahippocampal atrophy occurs at a similar rate regardless of diagnostic group. Those who develop dementia may have smaller hippocampi to begin with, but become symptomatic because of accelerated loss of temporal lobe volume. Temporal lobe volume loss may mark the beginning of the disease process within six years prior to dementia onset.

Original languageEnglish (US)
Pages (from-to)1297-1304
Number of pages8
JournalNeurology
Volume48
Issue number5
StatePublished - May 1997

Fingerprint

Temporal Lobe
Dementia
Hippocampus
Atrophy
Neurofibrillary Tangles
Alzheimer Disease
Prospective Studies
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kaye, J., Swihart, T., Howieson, D., Dame, A., Moore, M. M., Karnos, T., ... Sexton, G. (1997). Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology, 48(5), 1297-1304.

Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. / Kaye, Jeffrey; Swihart, T.; Howieson, Diane; Dame, A.; Moore, M. M.; Karnos, T.; Camicioli, R.; Ball, M.; Oken, Barry; Sexton, G.

In: Neurology, Vol. 48, No. 5, 05.1997, p. 1297-1304.

Research output: Contribution to journalArticle

Kaye, J, Swihart, T, Howieson, D, Dame, A, Moore, MM, Karnos, T, Camicioli, R, Ball, M, Oken, B & Sexton, G 1997, 'Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia', Neurology, vol. 48, no. 5, pp. 1297-1304.
Kaye J, Swihart T, Howieson D, Dame A, Moore MM, Karnos T et al. Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology. 1997 May;48(5):1297-1304.
Kaye, Jeffrey ; Swihart, T. ; Howieson, Diane ; Dame, A. ; Moore, M. M. ; Karnos, T. ; Camicioli, R. ; Ball, M. ; Oken, Barry ; Sexton, G. / Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. In: Neurology. 1997 ; Vol. 48, No. 5. pp. 1297-1304.
@article{fafb8c032433412d9bf27e1013b23707,
title = "Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia",
abstract = "Objective: To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and parahippocampus) in preclinical dementia. Background: Postmortem studies suggest that the earliest changes in Alzheimer's disease are neurofibrillary tangle formation in hippocampus and adjacent cortex. MRI volume analysis of temporal lobe structures over time in subjects prior to developing dementia may allow the identification of when these processes begin, the rate they develop, and which areas are key to symptom development. Methods: 30 nondemented (NoD), healthy, elderly individuals enrolled in a prospective study of healthy aging evaluated annually over a mean of 42 months. Twelve subjects with subsequent cognitive decline were assigned to the preclinical dementia group (PreD). All 120 annual MRI studies analyzed by volumetric techniques assessed group differences in temporal lobe volumes and rates of brain loss. Results: NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume. Rates of volume loss between the groups did not significantly differ. PreD cases had significantly smaller hippocampi when asymptomatic. Parahippocampal volume did not differ between PreD and NoD cases. Significant time-dependent temporal lobe atrophy was present only in PreD. Conclusions: Hippocampal and parahippocampal atrophy occurs at a similar rate regardless of diagnostic group. Those who develop dementia may have smaller hippocampi to begin with, but become symptomatic because of accelerated loss of temporal lobe volume. Temporal lobe volume loss may mark the beginning of the disease process within six years prior to dementia onset.",
author = "Jeffrey Kaye and T. Swihart and Diane Howieson and A. Dame and Moore, {M. M.} and T. Karnos and R. Camicioli and M. Ball and Barry Oken and G. Sexton",
year = "1997",
month = "5",
language = "English (US)",
volume = "48",
pages = "1297--1304",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia

AU - Kaye, Jeffrey

AU - Swihart, T.

AU - Howieson, Diane

AU - Dame, A.

AU - Moore, M. M.

AU - Karnos, T.

AU - Camicioli, R.

AU - Ball, M.

AU - Oken, Barry

AU - Sexton, G.

PY - 1997/5

Y1 - 1997/5

N2 - Objective: To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and parahippocampus) in preclinical dementia. Background: Postmortem studies suggest that the earliest changes in Alzheimer's disease are neurofibrillary tangle formation in hippocampus and adjacent cortex. MRI volume analysis of temporal lobe structures over time in subjects prior to developing dementia may allow the identification of when these processes begin, the rate they develop, and which areas are key to symptom development. Methods: 30 nondemented (NoD), healthy, elderly individuals enrolled in a prospective study of healthy aging evaluated annually over a mean of 42 months. Twelve subjects with subsequent cognitive decline were assigned to the preclinical dementia group (PreD). All 120 annual MRI studies analyzed by volumetric techniques assessed group differences in temporal lobe volumes and rates of brain loss. Results: NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume. Rates of volume loss between the groups did not significantly differ. PreD cases had significantly smaller hippocampi when asymptomatic. Parahippocampal volume did not differ between PreD and NoD cases. Significant time-dependent temporal lobe atrophy was present only in PreD. Conclusions: Hippocampal and parahippocampal atrophy occurs at a similar rate regardless of diagnostic group. Those who develop dementia may have smaller hippocampi to begin with, but become symptomatic because of accelerated loss of temporal lobe volume. Temporal lobe volume loss may mark the beginning of the disease process within six years prior to dementia onset.

AB - Objective: To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and parahippocampus) in preclinical dementia. Background: Postmortem studies suggest that the earliest changes in Alzheimer's disease are neurofibrillary tangle formation in hippocampus and adjacent cortex. MRI volume analysis of temporal lobe structures over time in subjects prior to developing dementia may allow the identification of when these processes begin, the rate they develop, and which areas are key to symptom development. Methods: 30 nondemented (NoD), healthy, elderly individuals enrolled in a prospective study of healthy aging evaluated annually over a mean of 42 months. Twelve subjects with subsequent cognitive decline were assigned to the preclinical dementia group (PreD). All 120 annual MRI studies analyzed by volumetric techniques assessed group differences in temporal lobe volumes and rates of brain loss. Results: NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume. Rates of volume loss between the groups did not significantly differ. PreD cases had significantly smaller hippocampi when asymptomatic. Parahippocampal volume did not differ between PreD and NoD cases. Significant time-dependent temporal lobe atrophy was present only in PreD. Conclusions: Hippocampal and parahippocampal atrophy occurs at a similar rate regardless of diagnostic group. Those who develop dementia may have smaller hippocampi to begin with, but become symptomatic because of accelerated loss of temporal lobe volume. Temporal lobe volume loss may mark the beginning of the disease process within six years prior to dementia onset.

UR - http://www.scopus.com/inward/record.url?scp=0030938170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030938170&partnerID=8YFLogxK

M3 - Article

C2 - 9153461

AN - SCOPUS:0030938170

VL - 48

SP - 1297

EP - 1304

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5

ER -