Volatile metabolites in sera of normal and diabetic patients

Albert Zlatkis, Colin F. Poole, Roswitha Brazeli, Donald A. Bafus, Peter Spencer

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The profiles of volatile metabolites in serum samples from normal individuals and from individuals with diabetes mellitus with varying degrees of polyneuropathy have been studied. The transevaporator procedure was used to obtain sample extracts which were chromatographed on a highly efficient glass column coated with Silar 10C (106 m × 0.25 mm I.D.). Differences in profiles between normal subjects and diabetic subjects on no drug therapy were noticed. However, correlations between the severity of the neuropathy and the concentrations of certain ketones could not be established. Compounds present both in diabetic and normal sera have been identified by mass spectrometry.

Original languageEnglish (US)
Pages (from-to)137-145
Number of pages9
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume182
Issue number2
DOIs
StatePublished - May 9 1980
Externally publishedYes

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Drug therapy
Medical problems
Metabolites
Ketones
Mass spectrometry
Glass
Polyneuropathies
Serum
Mass Spectrometry
Diabetes Mellitus
Drug Therapy
silar 10C

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Volatile metabolites in sera of normal and diabetic patients. / Zlatkis, Albert; Poole, Colin F.; Brazeli, Roswitha; Bafus, Donald A.; Spencer, Peter.

In: Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 182, No. 2, 09.05.1980, p. 137-145.

Research output: Contribution to journalArticle

Zlatkis, Albert ; Poole, Colin F. ; Brazeli, Roswitha ; Bafus, Donald A. ; Spencer, Peter. / Volatile metabolites in sera of normal and diabetic patients. In: Journal of Chromatography B: Biomedical Sciences and Applications. 1980 ; Vol. 182, No. 2. pp. 137-145.
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