Volatile metabolites in sera of normal and diabetic patients

Albert Zlatkis; Colin F. Poole; Roswitha Brazeli; Donald A. Bafus; Peter S. Spencer

doi:10.1016/S0378-4347(00)81617-5

Volatile metabolites in sera of normal and diabetic patients

Albert Zlatkis, Colin F. Poole, Roswitha Brazeli, Donald A. Bafus, Peter S. Spencer

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The profiles of volatile metabolites in serum samples from normal individuals and from individuals with diabetes mellitus with varying degrees of polyneuropathy have been studied. The transevaporator procedure was used to obtain sample extracts which were chromatographed on a highly efficient glass column coated with Silar 10C (106 m × 0.25 mm I.D.). Differences in profiles between normal subjects and diabetic subjects on no drug therapy were noticed. However, correlations between the severity of the neuropathy and the concentrations of certain ketones could not be established. Compounds present both in diabetic and normal sera have been identified by mass spectrometry.

Original language	English (US)
Pages (from-to)	137-145
Number of pages	9
Journal	Journal of Chromatography B: Biomedical Sciences and Applications
Volume	182
Issue number	2
DOIs	https://doi.org/10.1016/S0378-4347(00)81617-5
State	Published - May 9 1980
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1016/S0378-4347(00)81617-5

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abstract = "The profiles of volatile metabolites in serum samples from normal individuals and from individuals with diabetes mellitus with varying degrees of polyneuropathy have been studied. The transevaporator procedure was used to obtain sample extracts which were chromatographed on a highly efficient glass column coated with Silar 10C (106 m × 0.25 mm I.D.). Differences in profiles between normal subjects and diabetic subjects on no drug therapy were noticed. However, correlations between the severity of the neuropathy and the concentrations of certain ketones could not be established. Compounds present both in diabetic and normal sera have been identified by mass spectrometry.",

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note = "Funding Information: Supported in part by the National Institute of Occupational Safety and Health Grant No. OH 00535. Thanks are due to Dr. Amold Steman for his assistance in this project.",

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AU - Poole, Colin F.

AU - Brazeli, Roswitha

AU - Bafus, Donald A.

AU - Spencer, Peter S.

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Volatile metabolites in sera of normal and diabetic patients

Abstract

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