Abstract
Purpose: This study tested a prediction stemming from the hypothesis that anastrozole users experience heightened vitreo-retinal traction. This hypothesis was based on the knowledge that menopause increases the risk of intraocular tractional events such as posterior vitreous detachments (PVDs). Methods: Retinal thickness was measured for 3 groups of amenorrheic women: (1) anastrozole users and (2) tamoxifen users undergoing adjuvant therapy for early-stage breast cancer, and (3) control subjects not using hormonal medication. Foveal shape indices were derived for subjects without PVDs. Results: For anastrozole users, the distance to the temporal side of the fovea became less than the distance to the nasal side at a sufficient height above the foveal base. This effect did not exist for control subjects; the between-group difference was appreciable. Results concerning tamoxifen users were inconclusive. Conclusions: The foveas of women using anastrozole appear to be subjected to more tractional force than are the foveas of women not using any hormonal medication.
Original language | English (US) |
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Pages (from-to) | 9-16 |
Number of pages | 8 |
Journal | Breast Cancer Research and Treatment |
Volume | 117 |
Issue number | 1 |
DOIs | |
State | Published - Sep 2009 |
Keywords
- Aromatase inhibitor
- Estrogen
- Eye
- Optical coherence tomography
- Retina
- Vitreous
ASJC Scopus subject areas
- Oncology
- Cancer Research