TY - JOUR
T1 - Vitiligo in patients with metastatic melanoma
T2 - A good prognostic sign
AU - Nordlund, James J.
AU - Kirkwood, John M.
AU - Forget, Bernadette M.
AU - Milton, Gerard
AU - Albert, Daniel M.
AU - Lerner, Aaron B.
PY - 1983
Y1 - 1983
N2 - We have identified and studied twenty-seven patients with melanoma who also had vitiligo Four patients had vitiligo before the diagnosis of melanoma, and twenty-three developed depigmentation after the diagnosis of malignancy We also have reviewed published reports about twenty-four other patients with melanoma who developed vitiligo The clinical course of the melanoma in the fifty-one patients was remarkably similar Thirty-seven had a melanoma arising at a site which tends to carry a poor prognosis, for example, on the trunk, under the nail, or on the mucous membranes Forty-nine patients had metastases in regional lymph nodes or at distal sites Thirty-three patients survived 5 years, and twenty-five survived 10 years These data suggest that the appearance of vitiligo in patients with metastatic melanoma portends a longer survival than expected The patients with vitiligo are not necessarily cured and eventually may succumb to metastatic disease We were unable to determine whether the vitiligo caused retardation of tumor growth or whether the melanoma caused vitiligo
AB - We have identified and studied twenty-seven patients with melanoma who also had vitiligo Four patients had vitiligo before the diagnosis of melanoma, and twenty-three developed depigmentation after the diagnosis of malignancy We also have reviewed published reports about twenty-four other patients with melanoma who developed vitiligo The clinical course of the melanoma in the fifty-one patients was remarkably similar Thirty-seven had a melanoma arising at a site which tends to carry a poor prognosis, for example, on the trunk, under the nail, or on the mucous membranes Forty-nine patients had metastases in regional lymph nodes or at distal sites Thirty-three patients survived 5 years, and twenty-five survived 10 years These data suggest that the appearance of vitiligo in patients with metastatic melanoma portends a longer survival than expected The patients with vitiligo are not necessarily cured and eventually may succumb to metastatic disease We were unable to determine whether the vitiligo caused retardation of tumor growth or whether the melanoma caused vitiligo
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U2 - 10.1016/S0190-9622(83)70182-9
DO - 10.1016/S0190-9622(83)70182-9
M3 - Article
C2 - 6643767
AN - SCOPUS:0021079551
SN - 0190-9622
VL - 9
SP - 689
EP - 696
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -