Vitamin-mineral treatment improves aggression and emotional regulation in children with ADHD

a fully blinded, randomized, placebo-controlled trial

Julia J. Rucklidge, Matthew J.F. Eggleston, Jeni Johnstone, Kathryn Darling, Chris M. Frampton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Evaluation of broad-spectrum micronutrient (vitamins and minerals) treatment for childhood ADHD has been limited to open-label studies that highlight beneficial effects across many aspects of psychological functioning. Method: This is the first fully blinded randomized controlled trial of medication-free children (n = 93) with ADHD (7–12 years) assigned to either micronutrients (n = 47) or placebo (n = 46) in a 1:1 ratio, for 10 weeks. All children received standardized ADHD assessments. Data were collected from clinicians, parents, participants and teachers across a range of measures assessing ADHD symptoms, general functioning and impairment, mood, aggression and emotional regulation. Results: Intent-to-treat analyses showed significant between-group differences favouring micronutrient treatment on the Clinical Global Impression-Improvement (ES = 0.46), with 47% of those on micronutrients identified as ‘much’ to ‘very much’ improved versus 28% on placebo. No group differences were identified on clinician, parent and teacher ratings of overall ADHD symptoms (ES ranged 0.03–0.17). However, according to clinicians, 32% of those on micronutrients versus 9% of those on placebo showed a clinically meaningful improvement on inattentive (OR = 4.9; 95% CI: 1.5–16.3), but no group differences on improvement in hyperactive-impulsive symptoms (OR = 1.0; 95% CI: 0.4–2.5). Based on clinician, parent and teacher report, those on micronutrients showed greater improvements in emotional regulation, aggression and general functioning compared to placebo (ES ranged 0.35–0.66). There were two dropouts per group, no group differences in adverse events and no serious adverse events identified. Blinding was successful with guessing no better than chance. Conclusions: Micronutrients improved overall function, reduced impairment and improved inattention, emotional regulation and aggression, but not hyperactive/impulsive symptoms, in this sample of children with ADHD. Although direct benefit for core ADHD symptoms was modest, with mixed findings across raters, the low rate of adverse effects and the benefits reported across multiple areas of functioning indicate micronutrients may be a favourable option for some children, particularly those with both ADHD and emotional dysregulation. Trial registered with the Australian New Zealand Clinical Trials Registry ACTRN12613000896774.

Original languageEnglish (US)
Pages (from-to)232-246
Number of pages15
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume59
Issue number3
DOIs
StatePublished - Mar 1 2018

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Micronutrients
Aggression
Vitamins
Minerals
Randomized Controlled Trials
Placebos
Therapeutics
New Zealand
Registries
Parents
Clinical Trials
Psychology

Keywords

  • ADHD
  • aggression
  • micronutrient
  • mineral
  • Mood
  • Treatment
  • vitamin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Vitamin-mineral treatment improves aggression and emotional regulation in children with ADHD : a fully blinded, randomized, placebo-controlled trial. / Rucklidge, Julia J.; Eggleston, Matthew J.F.; Johnstone, Jeni; Darling, Kathryn; Frampton, Chris M.

In: Journal of Child Psychology and Psychiatry and Allied Disciplines, Vol. 59, No. 3, 01.03.2018, p. 232-246.

Research output: Contribution to journalArticle

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