TY - JOUR
T1 - Vitamin D3 Supplementation During Pregnancy and Lactation Improves Vitamin D Status of the Mother–Infant Dyad
AU - Thiele, Doria K.
AU - Ralph, Jody
AU - El-Masri, Maher
AU - Anderson, Cindy M.
N1 - Publisher Copyright:
© 2017 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective To identify the combined effect of prenatal and postnatal vitamin D3 supplementation on the vitamin D status of pregnant and lactating women and their exclusively breastfed infants. Design Double-blind, randomized controlled trial. Setting Upper Midwestern U.S., hospital-based obstetric practice. Participants Pregnant women (N = 13) planning to exclusively breastfeed were randomized at 24 to 28 weeks gestation to receive vitamin D3 at a dosage of 400 IU (control group, n = 6) or 3,800 IU (intervention group, n = 7) daily through 4 to 6 weeks postpartum. Vitamin D status was determined at enrollment and in mother–infant dyads at 24 to 72 hours after birth and 4 to 6 weeks postpartum. Methods Serum 25-hydroxyvitamin D levels were measured to determine the effect of vitamin D3 supplementation on the vitamin D status of mothers and infants. Analysis of covariance was used to compare differences in 25-hydroxyvitamin D levels between the control and intervention groups. Results The mothers’ vitamin D levels were significantly higher in the intervention group than in the control group at birth (p =.044) and at 4 to 6 weeks postpartum (p =.002). Infants in the intervention group had significantly higher vitamin D levels at birth (p =.021) and nonsignificant, clinically relevant increases at 4 to 6 weeks of age (p =.256). No differences were found between maternal groups in serum calcium or parathyroid hormone levels. Conclusion Prenatal to postpartum vitamin D3 supplementation is an effective intervention to increase a mother's vitamin D status and to promote optimal vitamin D status in newborns and exclusively breastfed infants.
AB - Objective To identify the combined effect of prenatal and postnatal vitamin D3 supplementation on the vitamin D status of pregnant and lactating women and their exclusively breastfed infants. Design Double-blind, randomized controlled trial. Setting Upper Midwestern U.S., hospital-based obstetric practice. Participants Pregnant women (N = 13) planning to exclusively breastfeed were randomized at 24 to 28 weeks gestation to receive vitamin D3 at a dosage of 400 IU (control group, n = 6) or 3,800 IU (intervention group, n = 7) daily through 4 to 6 weeks postpartum. Vitamin D status was determined at enrollment and in mother–infant dyads at 24 to 72 hours after birth and 4 to 6 weeks postpartum. Methods Serum 25-hydroxyvitamin D levels were measured to determine the effect of vitamin D3 supplementation on the vitamin D status of mothers and infants. Analysis of covariance was used to compare differences in 25-hydroxyvitamin D levels between the control and intervention groups. Results The mothers’ vitamin D levels were significantly higher in the intervention group than in the control group at birth (p =.044) and at 4 to 6 weeks postpartum (p =.002). Infants in the intervention group had significantly higher vitamin D levels at birth (p =.021) and nonsignificant, clinically relevant increases at 4 to 6 weeks of age (p =.256). No differences were found between maternal groups in serum calcium or parathyroid hormone levels. Conclusion Prenatal to postpartum vitamin D3 supplementation is an effective intervention to increase a mother's vitamin D status and to promote optimal vitamin D status in newborns and exclusively breastfed infants.
KW - breastfeeding
KW - vitamin D deficiency
KW - vitamin D3 supplementation
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U2 - 10.1016/j.jogn.2016.02.016
DO - 10.1016/j.jogn.2016.02.016
M3 - Article
C2 - 27840206
AN - SCOPUS:85007478575
SN - 0884-2175
VL - 46
SP - 135
EP - 147
JO - JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing
JF - JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing
IS - 1
ER -