Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2

E. R. Morey-Holton, H. K. Schnoes, H. F. DeLuca, M. E. Phelps, Robert Klein, R. H. Nissenson, C. D. Arnaud

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The purpose of this study was to determine whether plasma levels of the vitamin D hormone and parathyroid hormone (PTH), two potent activators of bone remodeling sites, were altered in four astronauts during the 8-day (d) Spacelab 2 mission (SL2). Increased circulating levels of either hormone could change calcium homeostasis and bone cell activity and, thus, contribute to bone loss in crewmembers in space. The vitamin D hormone was elevated in all astronauts at the end of the first inflight day but returned to normal by the seventh day. Biologically active PTH tended to be normal throughout the mission. Both hormones were within the normal range by the end of the 8-d flight of this SL2 crew. Plasma levels of 25OHD, 24,25(OH)2D, calcium, phosphorus, and albumin were essentially normal during the mission.

Original languageEnglish (US)
Pages (from-to)1038-1041
Number of pages4
JournalAviation Space and Environmental Medicine
Volume59
Issue number11
StatePublished - 1988
Externally publishedYes

Fingerprint

Vitamins
Hormones
Metabolites
Parathyroid Hormone
Vitamin D
Astronauts
Bone
Calcium
Plasmas
Bone and Bones
Bone Remodeling
Phosphorus
Albumins
Reference Values
Homeostasis

ASJC Scopus subject areas

  • Pollution
  • Medicine(all)
  • Public Health, Environmental and Occupational Health

Cite this

Morey-Holton, E. R., Schnoes, H. K., DeLuca, H. F., Phelps, M. E., Klein, R., Nissenson, R. H., & Arnaud, C. D. (1988). Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2. Aviation Space and Environmental Medicine, 59(11), 1038-1041.

Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2. / Morey-Holton, E. R.; Schnoes, H. K.; DeLuca, H. F.; Phelps, M. E.; Klein, Robert; Nissenson, R. H.; Arnaud, C. D.

In: Aviation Space and Environmental Medicine, Vol. 59, No. 11, 1988, p. 1038-1041.

Research output: Contribution to journalArticle

Morey-Holton, ER, Schnoes, HK, DeLuca, HF, Phelps, ME, Klein, R, Nissenson, RH & Arnaud, CD 1988, 'Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2', Aviation Space and Environmental Medicine, vol. 59, no. 11, pp. 1038-1041.
Morey-Holton ER, Schnoes HK, DeLuca HF, Phelps ME, Klein R, Nissenson RH et al. Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2. Aviation Space and Environmental Medicine. 1988;59(11):1038-1041.
Morey-Holton, E. R. ; Schnoes, H. K. ; DeLuca, H. F. ; Phelps, M. E. ; Klein, Robert ; Nissenson, R. H. ; Arnaud, C. D. / Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2. In: Aviation Space and Environmental Medicine. 1988 ; Vol. 59, No. 11. pp. 1038-1041.
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