Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis

Sabrina Paganoni, Eric A. Macklin, Chafic Karam, Hong Yu, Fernando Gonterman, K. Ashley Fetterman, Merit Cudkowicz, James Berry, Anne Marie Wills

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: The objective of this study was to determine whether serum vitamin D [25(OH)D] levels are associated with disease progression in amyotrophic lateral sclerosis (ALS). Methods: 25(OH)D was measured in subjects enrolled in a multicenter study for validation of ALS biomarkers. Baseline 25(OH)D levels were correlated with baseline ALSFRS-R scores. Average 25(OH)D levels from baseline and month 6 visits (seasonally asynchronous) were used to predict subsequent rate of change in ALSFRS-R from month 6 to month 18. Results: Most subjects had either insufficient or deficient 25(OH)D levels. Lower 25(OH)D was associated with lower ALSFRS-R gross motor scores, but not lower ALSFRS-R total scores at baseline. Levels of 25(OH)D were not predictive of disease progression over the next 12 months. Conclusion: 25(OH)D was associated with baseline gross motor ALSFRS-R scores but did not predict the rate of disease progression. Vitamin D levels may reflect poor mobility in patients with ALS.

Original languageEnglish (US)
JournalMuscle and Nerve
DOIs
StateAccepted/In press - 2017

Fingerprint

Amyotrophic Lateral Sclerosis
Vitamin D
Disease Progression
Multicenter Studies
Biomarkers
Serum

Keywords

  • Biomarker
  • Disease progression
  • Gross motor function
  • Predictor
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Paganoni, S., Macklin, E. A., Karam, C., Yu, H., Gonterman, F., Fetterman, K. A., ... Wills, A. M. (Accepted/In press). Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis. Muscle and Nerve. https://doi.org/10.1002/mus.25555

Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis. / Paganoni, Sabrina; Macklin, Eric A.; Karam, Chafic; Yu, Hong; Gonterman, Fernando; Fetterman, K. Ashley; Cudkowicz, Merit; Berry, James; Wills, Anne Marie.

In: Muscle and Nerve, 2017.

Research output: Contribution to journalArticle

Paganoni, S, Macklin, EA, Karam, C, Yu, H, Gonterman, F, Fetterman, KA, Cudkowicz, M, Berry, J & Wills, AM 2017, 'Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis', Muscle and Nerve. https://doi.org/10.1002/mus.25555
Paganoni, Sabrina ; Macklin, Eric A. ; Karam, Chafic ; Yu, Hong ; Gonterman, Fernando ; Fetterman, K. Ashley ; Cudkowicz, Merit ; Berry, James ; Wills, Anne Marie. / Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis. In: Muscle and Nerve. 2017.
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AU - Macklin, Eric A.

AU - Karam, Chafic

AU - Yu, Hong

AU - Gonterman, Fernando

AU - Fetterman, K. Ashley

AU - Cudkowicz, Merit

AU - Berry, James

AU - Wills, Anne Marie

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N2 - Introduction: The objective of this study was to determine whether serum vitamin D [25(OH)D] levels are associated with disease progression in amyotrophic lateral sclerosis (ALS). Methods: 25(OH)D was measured in subjects enrolled in a multicenter study for validation of ALS biomarkers. Baseline 25(OH)D levels were correlated with baseline ALSFRS-R scores. Average 25(OH)D levels from baseline and month 6 visits (seasonally asynchronous) were used to predict subsequent rate of change in ALSFRS-R from month 6 to month 18. Results: Most subjects had either insufficient or deficient 25(OH)D levels. Lower 25(OH)D was associated with lower ALSFRS-R gross motor scores, but not lower ALSFRS-R total scores at baseline. Levels of 25(OH)D were not predictive of disease progression over the next 12 months. Conclusion: 25(OH)D was associated with baseline gross motor ALSFRS-R scores but did not predict the rate of disease progression. Vitamin D levels may reflect poor mobility in patients with ALS.

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