TY - JOUR
T1 - Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson’s disease
AU - Specketer, Krista
AU - Zabetian, Cyrus P.
AU - Edwards, Karen L.
AU - Tian, Lu
AU - Quinn, Joseph F.
AU - Peterson-Hiller, Amie L.
AU - Chung, Kathryn A.
AU - Hu, Shu Ching
AU - Montine, Thomas J.
AU - Cholerton, Brenna A.
N1 - Funding Information:
This study was supported by the Department of Veterans Affairs and National Institutes of Neurological Disorders and Stroke (P50 NS0662684). This material is the result of work supported with resources and the use of facilities at the VA Puget Sound Health Care System. The funding sources did not provide scientific input for the study. We sincerely thank our research subjects and family members for their participation in this study.
Funding Information:
This study was supported by the Department of Veterans Affairs and National Institutes of Neurological Disorders and Stroke (P50 NS0662684). This study was supported by the Department of Veterans Affairs and National Institutes of Neurological Disorders and Stroke (P50 NS0662684). This material is the result of work supported with resources and the use of facilities at the VA Puget Sound Health Care System. The funding sources did not provide scientific input for the study. We sincerely thank our research subjects and family members for their participation in this study.
Funding Information:
This study was supported by the Department of Veterans Affairs and National Institutes of Neurological Disorders and Stroke (P50 NS0662684).
Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/9/14
Y1 - 2019/9/14
N2 - Introduction: Cognitive impairment is a common symptom of Parkinson’s disease (PD) associated with reduced quality of life and a more severe disease state. Previous research has shown an association between visuospatial dysfunction and worse disease course; however, it is not clear whether this is separable from executive dysfunction and/or dementia. This study sought to determine whether distinct cognitive factors could be measured in a large PD cohort, and if those factors were differentially associated with other PD-related features, specifically to provide insight into visuospatial dysfunction. Methods: Non-demented participants with PD from the Pacific Udall Center were enrolled (n = 197). Co-participants (n = 104) completed questionnaires when available. Principal components factor analysis (PCFA) was utilized to group the neuropsychological test scores into independent factors by considering those with big factor loading (≥.40). Linear and logistic regression analyses were performed to examine the relationship between the cognitive factors identified in the PCFA and other clinical features of PD. Results: Six factors were extracted from the PCFA: 1) executive/processing speed, 2) visual learning & memory/visuospatial, 3) auditory working memory, 4) contextual verbal memory, 5) semantic learning & memory, and 6) visuospatial. Motor severity (p = 0.001), mood (p < 0.001), and performance on activities of daily living scores (informant: p < 0.001, patient: p = 0.009) were primarily associated with frontal and executive factors. General sleep disturbance (p < 0.006) and hallucinations (p = 0.002) were primarily associated with visuospatial functioning and visual learning/memory. Conclusions: Motor symptoms, mood, and performance on activities of daily living were primarily associated with frontal/executive factors. Sleep disturbance and hallucinations were associated with visuospatial functioning and visual learning/memory only, over and above executive functioning and regardless of cognitive disease severity. These findings support that visuospatial function in PD may indicate a more severe disease course, and that symptom management should be guided accordingly.
AB - Introduction: Cognitive impairment is a common symptom of Parkinson’s disease (PD) associated with reduced quality of life and a more severe disease state. Previous research has shown an association between visuospatial dysfunction and worse disease course; however, it is not clear whether this is separable from executive dysfunction and/or dementia. This study sought to determine whether distinct cognitive factors could be measured in a large PD cohort, and if those factors were differentially associated with other PD-related features, specifically to provide insight into visuospatial dysfunction. Methods: Non-demented participants with PD from the Pacific Udall Center were enrolled (n = 197). Co-participants (n = 104) completed questionnaires when available. Principal components factor analysis (PCFA) was utilized to group the neuropsychological test scores into independent factors by considering those with big factor loading (≥.40). Linear and logistic regression analyses were performed to examine the relationship between the cognitive factors identified in the PCFA and other clinical features of PD. Results: Six factors were extracted from the PCFA: 1) executive/processing speed, 2) visual learning & memory/visuospatial, 3) auditory working memory, 4) contextual verbal memory, 5) semantic learning & memory, and 6) visuospatial. Motor severity (p = 0.001), mood (p < 0.001), and performance on activities of daily living scores (informant: p < 0.001, patient: p = 0.009) were primarily associated with frontal and executive factors. General sleep disturbance (p < 0.006) and hallucinations (p = 0.002) were primarily associated with visuospatial functioning and visual learning/memory. Conclusions: Motor symptoms, mood, and performance on activities of daily living were primarily associated with frontal/executive factors. Sleep disturbance and hallucinations were associated with visuospatial functioning and visual learning/memory only, over and above executive functioning and regardless of cognitive disease severity. These findings support that visuospatial function in PD may indicate a more severe disease course, and that symptom management should be guided accordingly.
KW - Aging
KW - Parkinson’s disease
KW - cognition
KW - neuropsychological assessment
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UR - http://www.scopus.com/inward/citedby.url?scp=85067585607&partnerID=8YFLogxK
U2 - 10.1080/13803395.2019.1623180
DO - 10.1080/13803395.2019.1623180
M3 - Article
C2 - 31177941
AN - SCOPUS:85067585607
VL - 41
SP - 803
EP - 813
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 0168-8634
IS - 8
ER -