TY - JOUR
T1 - Visualization of chicken embryo heart motion
AU - Phan, Ly
AU - Rugonyi, Sandra
AU - Grimm, Cindy
N1 - Funding Information:
This research was funded in part by NSF [grant number DBI-1052688], [grant number IIS-1302142] and NIH [grant number R01-HL094570]. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the sponsors.
Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/3/4
Y1 - 2018/3/4
N2 - We present a geometric surface parameterisation algorithm and multiple visualisation techniques (cross-sectional area and shape change, peristaltic motion, stress/strain, volume change, surface curvature change several visualisation techniques) adapted to the problem of understanding the 4D peristaltic-like motion of the outflow tract (OFT) in an embryonic chick heart. We illustrated the techniques using data from hearts under normal conditions (four embryos), and hearts in which blood flow conditions are altered through OFT banding (four embryos). The overall goal is to create quantitative measures of the temporal heart shape change both within a single subject and between multiple subjects. These measures will help elucidate how altering hemodynamic conditions changes the shape and motion of the OFT walls, which in turn influence the stresses and strains on the developing heart, causing it to develop differently. We take advantage of the tubular shape and periodic motion of the OFT to produce successively lower dimensional visualisations of the cardiac motion (e.g. curvature, volume and cross section) over time, and quantifications of such visualisations. These visualisations enable a more fine-grained understanding of how the contraction wave moves through the OFT and the cross-sectional shape change that accompanies it.
AB - We present a geometric surface parameterisation algorithm and multiple visualisation techniques (cross-sectional area and shape change, peristaltic motion, stress/strain, volume change, surface curvature change several visualisation techniques) adapted to the problem of understanding the 4D peristaltic-like motion of the outflow tract (OFT) in an embryonic chick heart. We illustrated the techniques using data from hearts under normal conditions (four embryos), and hearts in which blood flow conditions are altered through OFT banding (four embryos). The overall goal is to create quantitative measures of the temporal heart shape change both within a single subject and between multiple subjects. These measures will help elucidate how altering hemodynamic conditions changes the shape and motion of the OFT walls, which in turn influence the stresses and strains on the developing heart, causing it to develop differently. We take advantage of the tubular shape and periodic motion of the OFT to produce successively lower dimensional visualisations of the cardiac motion (e.g. curvature, volume and cross section) over time, and quantifications of such visualisations. These visualisations enable a more fine-grained understanding of how the contraction wave moves through the OFT and the cross-sectional shape change that accompanies it.
KW - Heart development
KW - geodesic parameterisation
KW - out-flow tract
KW - surface reconstruction and parameterisation
KW - temporal visualisation
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U2 - 10.1080/21681163.2016.1222504
DO - 10.1080/21681163.2016.1222504
M3 - Article
AN - SCOPUS:84989259729
VL - 6
SP - 211
EP - 225
JO - Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization
JF - Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization
SN - 2168-1163
IS - 2
ER -