Visual and IOP outcomes after PRK in pigment dispersion syndrome

Kraig S. Bower, Rose K. Sia, Denise S. Ryan, Michael J. Mines, Richard Stutzman, Chrystyna P. Kuzmowych, Jennifer B. Eaddy, Charles D. Coe, Keith J. Wroblewski

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome. METHODS: The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications. RESULTS: Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5±6.9 years were included for review. At final follow-up, mean 404.1±119.5 days postoperative, UDVA was 20/15 or better in 67.6%, 20/20 or better in 91.9%, and 20/25 or better in 100% of eyes; 94.6% of eyes were within 0.50 diopters (D) and 100% were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73% and improved by one line in 27% of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7±3.8 mmHg) at 1 month (18.1±4.9 mmHg, P=.044) but unchanged at any other time postoperatively. Two (11%) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35±0.12) to final postoperative (0.35±0.13, P=.99). CONCLUSIONS: Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative.

Original languageEnglish (US)
Pages (from-to)686-690
Number of pages5
JournalJournal of Refractive Surgery
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

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Photorefractive Keratectomy
Intraocular Pressure
Visual Acuity
Steroids
Emmetropia
Glaucoma-Related Pigment Dispersion Syndrome
Safety
Incidence

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Bower, K. S., Sia, R. K., Ryan, D. S., Mines, M. J., Stutzman, R., Kuzmowych, C. P., ... Wroblewski, K. J. (2011). Visual and IOP outcomes after PRK in pigment dispersion syndrome. Journal of Refractive Surgery, 27(9), 686-690. https://doi.org/10.3928/1081597X-20110324-01

Visual and IOP outcomes after PRK in pigment dispersion syndrome. / Bower, Kraig S.; Sia, Rose K.; Ryan, Denise S.; Mines, Michael J.; Stutzman, Richard; Kuzmowych, Chrystyna P.; Eaddy, Jennifer B.; Coe, Charles D.; Wroblewski, Keith J.

In: Journal of Refractive Surgery, Vol. 27, No. 9, 01.09.2011, p. 686-690.

Research output: Contribution to journalArticle

Bower, KS, Sia, RK, Ryan, DS, Mines, MJ, Stutzman, R, Kuzmowych, CP, Eaddy, JB, Coe, CD & Wroblewski, KJ 2011, 'Visual and IOP outcomes after PRK in pigment dispersion syndrome', Journal of Refractive Surgery, vol. 27, no. 9, pp. 686-690. https://doi.org/10.3928/1081597X-20110324-01
Bower, Kraig S. ; Sia, Rose K. ; Ryan, Denise S. ; Mines, Michael J. ; Stutzman, Richard ; Kuzmowych, Chrystyna P. ; Eaddy, Jennifer B. ; Coe, Charles D. ; Wroblewski, Keith J. / Visual and IOP outcomes after PRK in pigment dispersion syndrome. In: Journal of Refractive Surgery. 2011 ; Vol. 27, No. 9. pp. 686-690.
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abstract = "PURPOSE: To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome. METHODS: The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications. RESULTS: Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5±6.9 years were included for review. At final follow-up, mean 404.1±119.5 days postoperative, UDVA was 20/15 or better in 67.6{\%}, 20/20 or better in 91.9{\%}, and 20/25 or better in 100{\%} of eyes; 94.6{\%} of eyes were within 0.50 diopters (D) and 100{\%} were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73{\%} and improved by one line in 27{\%} of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7±3.8 mmHg) at 1 month (18.1±4.9 mmHg, P=.044) but unchanged at any other time postoperatively. Two (11{\%}) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35±0.12) to final postoperative (0.35±0.13, P=.99). CONCLUSIONS: Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative.",
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AU - Bower, Kraig S.

AU - Sia, Rose K.

AU - Ryan, Denise S.

AU - Mines, Michael J.

AU - Stutzman, Richard

AU - Kuzmowych, Chrystyna P.

AU - Eaddy, Jennifer B.

AU - Coe, Charles D.

AU - Wroblewski, Keith J.

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N2 - PURPOSE: To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome. METHODS: The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications. RESULTS: Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5±6.9 years were included for review. At final follow-up, mean 404.1±119.5 days postoperative, UDVA was 20/15 or better in 67.6%, 20/20 or better in 91.9%, and 20/25 or better in 100% of eyes; 94.6% of eyes were within 0.50 diopters (D) and 100% were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73% and improved by one line in 27% of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7±3.8 mmHg) at 1 month (18.1±4.9 mmHg, P=.044) but unchanged at any other time postoperatively. Two (11%) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35±0.12) to final postoperative (0.35±0.13, P=.99). CONCLUSIONS: Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative.

AB - PURPOSE: To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome. METHODS: The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications. RESULTS: Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5±6.9 years were included for review. At final follow-up, mean 404.1±119.5 days postoperative, UDVA was 20/15 or better in 67.6%, 20/20 or better in 91.9%, and 20/25 or better in 100% of eyes; 94.6% of eyes were within 0.50 diopters (D) and 100% were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73% and improved by one line in 27% of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7±3.8 mmHg) at 1 month (18.1±4.9 mmHg, P=.044) but unchanged at any other time postoperatively. Two (11%) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35±0.12) to final postoperative (0.35±0.13, P=.99). CONCLUSIONS: Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative.

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