Visual aids for patient, family, and physician decision making about endovascular thrombectomy for acute ischemic stroke

Ivie Tokunboh, Marta Vales Montero, Matheus Fellipe Zopelaro Almeida, Latisha Sharma, Sidney Starkman, Viktor Szeder, Reza Jahan, David Liebeskind, Nestor Gonzalez, Andrew Demchuk, Michael T. Froehler, Mayank Goyal, Maarten G. Lansberg, Helmi Lutsep, Lee Schwamm, Jeffrey L. Saver

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background and Purpose-Rapid decision making optimizes outcomes from endovascular thrombectomy for acute cerebral ischemia. Visual displays facilitate swift review of potential outcomes and can accelerate decision processes. Methods-From patient-level, pooled randomized trial data, 100 person-icon arrays (Kuiper-Marshall personographs) were generated showing benefcial and adverse effects of endovascular thrombectomy for patients with acute cerebral ischemia and large vessel occlusion using (1) automated (algorithmic) and (2) expert-guided joint outcome table specifcation. Results-For the full 7-category modifed Rankin Scale, thrombectomy added to IV tPA (intravenous tissue-type plasminogen activator) alone had number needed to treat to beneft 2.9 (95% confdence interval, 2.6-3.3) and number needed to harm 68.9 (95% confdence interval, 40-250); thrombectomy for patients ineligible for IV tPA had number needed to treat to beneft 2.3 (95% confdence interval, 2.1-2.5) and number needed to harm 100 (95% confdence interval, 62.5-250). Visual displays of treatment effects on 100 patients showed: With thrombectomy added to IV tPA alone, 34 patients have better disability outcome, including 14 more normal or near normal (modifed Rankin Scale, 0-1); with thrombectomy for patients ineligible for IV tPA, 44 patients have a better disability outcome, including 16 more normal or nearly normal. Displays also showed that harm (increased modifed Rankin Scale fnal disability) occurred in 1 of 100 patients in both populations, mediated by increased new territory infarcts. The person-icon fgures integrated these outcomes, and early side-effects, in a single display. Conclusions-Visual decision aids are now available to rapidly educate healthcare providers, patients, and families about benefts and risks of endovascular thrombectomy, both when added to IV tPA in tPA-eligible patients and as the sole reperfusion treatment in tPA-ineligible patients.

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalStroke
Volume49
Issue number1
DOIs
StatePublished - 2018

Keywords

  • Decision making
  • Decision support techniques
  • Health personnel
  • Reperfusion
  • Thrombectomy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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