Abstract
Introduction: We evaluated visual acuity (VA) over 5 years in a subspecialty noninfectious uveitis population. Methods: Retrospective data from 5,530 noninfectious uveitis patients with anterior, intermediate, posterior or panuveitis were abstracted by expert reviewers. Mean VA was calculated using inverse probability of censoring weighting to account for losses to follow-up. Results: Patients were a median of 41 years old, 65% female, and 73% white. Initial mean VA was worse among panuveitis (20/84) than posterior (20/64), intermediate (20/47), and anterior (20/37) uveitides. On average, mean VA improved by 0.62, 0.51, 0.37, and 0.26 logMAR-equivalent lines over 2 years, respectively (each P <.001), then remained stable, except posterior uveitis mean VA worsened to initial levels. Conclusion: Mean VA of uveitic eyes improved and, typically, improvement was sustained under uveitis subspecialty care. Because VA tends to improve under tertiary care, mean VA change appears a better outcome for clinical studies than time-to-loss of VA.
| Original language | English (US) |
|---|---|
| Journal | Ocular Immunology and Inflammation |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- inverse probability of censoring weighting
- Uveitis
- Visual acuity
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology
Cite this
Visual Acuity Outcome over Time in Non-Infectious Uveitis. / Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group.
In: Ocular Immunology and Inflammation, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visual Acuity Outcome over Time in Non-Infectious Uveitis
AU - Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group
AU - Pistilli, Maxwell
AU - Joffe, Marshall M.
AU - Gangaputra, Sapna S.
AU - Pujari, Siddharth S.
AU - Jabs, Douglas A.
AU - Levy-Clarke, Grace A.
AU - Nussenblatt, Robert B.
AU - Rosenbaum, James T.
AU - Sen, H. Nida
AU - Suhler, Eric B.
AU - Thorne, Jennifer E.
AU - Bhatt, Nirali P.
AU - Foster, C. Stephen
AU - Begum, Hosne
AU - Fitzgerald, Tonetta D.
AU - Dreger, Kurt A.
AU - Altaweel, Michael M.
AU - Holbrook, Janet T.
AU - Kempen, John H.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Introduction: We evaluated visual acuity (VA) over 5 years in a subspecialty noninfectious uveitis population. Methods: Retrospective data from 5,530 noninfectious uveitis patients with anterior, intermediate, posterior or panuveitis were abstracted by expert reviewers. Mean VA was calculated using inverse probability of censoring weighting to account for losses to follow-up. Results: Patients were a median of 41 years old, 65% female, and 73% white. Initial mean VA was worse among panuveitis (20/84) than posterior (20/64), intermediate (20/47), and anterior (20/37) uveitides. On average, mean VA improved by 0.62, 0.51, 0.37, and 0.26 logMAR-equivalent lines over 2 years, respectively (each P <.001), then remained stable, except posterior uveitis mean VA worsened to initial levels. Conclusion: Mean VA of uveitic eyes improved and, typically, improvement was sustained under uveitis subspecialty care. Because VA tends to improve under tertiary care, mean VA change appears a better outcome for clinical studies than time-to-loss of VA.
AB - Introduction: We evaluated visual acuity (VA) over 5 years in a subspecialty noninfectious uveitis population. Methods: Retrospective data from 5,530 noninfectious uveitis patients with anterior, intermediate, posterior or panuveitis were abstracted by expert reviewers. Mean VA was calculated using inverse probability of censoring weighting to account for losses to follow-up. Results: Patients were a median of 41 years old, 65% female, and 73% white. Initial mean VA was worse among panuveitis (20/84) than posterior (20/64), intermediate (20/47), and anterior (20/37) uveitides. On average, mean VA improved by 0.62, 0.51, 0.37, and 0.26 logMAR-equivalent lines over 2 years, respectively (each P <.001), then remained stable, except posterior uveitis mean VA worsened to initial levels. Conclusion: Mean VA of uveitic eyes improved and, typically, improvement was sustained under uveitis subspecialty care. Because VA tends to improve under tertiary care, mean VA change appears a better outcome for clinical studies than time-to-loss of VA.
KW - inverse probability of censoring weighting
KW - Uveitis
KW - Visual acuity
UR - http://www.scopus.com/inward/record.url?scp=85076423607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076423607&partnerID=8YFLogxK
U2 - 10.1080/09273948.2019.1687733
DO - 10.1080/09273948.2019.1687733
M3 - Article
C2 - 31821051
AN - SCOPUS:85076423607
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
ER -