Visual acuity loss in rhesus monkey infants fed a taurine-free human infant formula

Martha Neuringer, J. Sturman

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    This study examined the effects of dietary taurine deprivation on visual development in rhesus monkeys. From birth to 3 months of age, rhesus monkeys were fed a taurine-free, soy protein-based infant formula, or the same formula supplemented with taurine. The early postnatal development of visual function was assessed with behavioral measurements of visual acuity. Plasma taurine levels in the taurine-deprived group fell to 35-50% of control values, as in human infants fed similar formulas. The visual acuity of the taurine-deprived infants was significantly impaired: acuity thresholds differed from control values by nearly a factor of 2 at 4, 8, and 12 weeks of age. The loss of acuity is associated with morphological changes in photoreceptors, particularly cones in the foveal region. These results provide direct evidence that taurine is essential for normal visual development in primates, and they support the nutritional importance of taurine for human infants.

    Original languageEnglish (US)
    Pages (from-to)597-601
    Number of pages5
    JournalJournal of Neuroscience Research
    Volume18
    Issue number4
    StatePublished - 1987

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    Infant Formula
    Taurine
    Macaca mulatta
    Visual Acuity
    Retinal Cone Photoreceptor Cells
    Soybean Proteins
    Nutritional Support
    Primates
    Parturition

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Visual acuity loss in rhesus monkey infants fed a taurine-free human infant formula. / Neuringer, Martha; Sturman, J.

    In: Journal of Neuroscience Research, Vol. 18, No. 4, 1987, p. 597-601.

    Research output: Contribution to journalArticle

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