Virus induces airway hyperresponsiveness to tachykinins: Role of neutral endopeptidase

D. J. Dusser, David Jacoby, T. D. Djokic, I. Rubinstein, D. B. Borson, J. A. Nadel

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

We examined the effects of viral respiratory infection by Sendai virus on airway responsiveness to tachykinins in guinea pigs. We measured the change in total pulmonary resistance induced by substance P or capsaicin in the presence or absence of the neutral endopeptidase inhibitor, phosphoramidon, in infected and in noninfected animals. In the absence of phosphoramidon, the bronchoconstrictor responses to substance P and to capsaicin were greater in infected than in noninfected animals. Phosphoramidon did not further potentiate the responses to substance P and to capsaicin in the infected animals, whereas it did so in noninfected animals. Studies performed in vitro showed that nonadrenergic noncholinergic bronchial smooth muscle responses to electrical field stimulation were also increased in tissues from infected animals and that phosphoramidon increased the response of tissues from noninfected animals greatly but increased the responses of tissues from infected animals only slightly. Responses to acetylcholine were unaffected by viral infection. Neutral endopeptidase activity was decreased by 40% in the tracheal epithelial layer of the infected animals. We suggest that respiratory infection by Sendai virus causes enhanced airway responsiveness to tachykinins by decreasing neutral endopeptidase-like activity in the airway epithelium.

Original languageEnglish (US)
Pages (from-to)1504-1511
Number of pages8
JournalJournal of Applied Physiology
Volume67
Issue number4
StatePublished - 1989
Externally publishedYes

Fingerprint

Tachykinins
Neprilysin
Viruses
Capsaicin
Substance P
Sendai virus
Virus Diseases
Respiratory Tract Infections
Bronchoconstrictor Agents
Protease Inhibitors
Electric Stimulation
Acetylcholine
Smooth Muscle
Guinea Pigs
Epithelium
Lung
phosphoramidon

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Dusser, D. J., Jacoby, D., Djokic, T. D., Rubinstein, I., Borson, D. B., & Nadel, J. A. (1989). Virus induces airway hyperresponsiveness to tachykinins: Role of neutral endopeptidase. Journal of Applied Physiology, 67(4), 1504-1511.

Virus induces airway hyperresponsiveness to tachykinins : Role of neutral endopeptidase. / Dusser, D. J.; Jacoby, David; Djokic, T. D.; Rubinstein, I.; Borson, D. B.; Nadel, J. A.

In: Journal of Applied Physiology, Vol. 67, No. 4, 1989, p. 1504-1511.

Research output: Contribution to journalArticle

Dusser, DJ, Jacoby, D, Djokic, TD, Rubinstein, I, Borson, DB & Nadel, JA 1989, 'Virus induces airway hyperresponsiveness to tachykinins: Role of neutral endopeptidase', Journal of Applied Physiology, vol. 67, no. 4, pp. 1504-1511.
Dusser, D. J. ; Jacoby, David ; Djokic, T. D. ; Rubinstein, I. ; Borson, D. B. ; Nadel, J. A. / Virus induces airway hyperresponsiveness to tachykinins : Role of neutral endopeptidase. In: Journal of Applied Physiology. 1989 ; Vol. 67, No. 4. pp. 1504-1511.
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