Virogenomics

A novel approach to antiviral drug discovery

Klaus Frueh, Kenneth Simmen, B. G Mattias Luukkonen, Yolanda C. Bell, Peter Ghazal

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Target discovery in virology has been limited to the few open-reading frames encoded by viral genomes. However, several recent examples show that inhibiting host-cell proteins can prevent viral infection. The human genome sequence should, therefore, contain many more genes that are essential for viral propagation than viral genomes. A systematic approach to find these potential cellular antiviral targets is global host gene expression analysis using DNA microarrays. Several recent studies reveal both unique and common strategies by which viruses change the gene expression profile of the host cell. Moreover, work in progress shows that some of the host pathways discovered by expression profiling are important for viral replication. Thus, human genomics tools have the potential to deliver novel antiviral drugs.

Original languageEnglish (US)
Pages (from-to)621-627
Number of pages7
JournalDrug Discovery Today
Volume6
Issue number12
DOIs
StatePublished - Jun 1 2001

Fingerprint

Viral Genome
Drug Discovery
Antiviral Agents
Virology
Viral Genes
Essential Genes
Human Genome
Virus Diseases
Genomics
Oligonucleotide Array Sequence Analysis
Transcriptome
Open Reading Frames
Viruses
Gene Expression
Proteins

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Frueh, K., Simmen, K., Luukkonen, B. G. M., Bell, Y. C., & Ghazal, P. (2001). Virogenomics: A novel approach to antiviral drug discovery. Drug Discovery Today, 6(12), 621-627. https://doi.org/10.1016/S1359-6446(01)01808-6

Virogenomics : A novel approach to antiviral drug discovery. / Frueh, Klaus; Simmen, Kenneth; Luukkonen, B. G Mattias; Bell, Yolanda C.; Ghazal, Peter.

In: Drug Discovery Today, Vol. 6, No. 12, 01.06.2001, p. 621-627.

Research output: Contribution to journalArticle

Frueh, K, Simmen, K, Luukkonen, BGM, Bell, YC & Ghazal, P 2001, 'Virogenomics: A novel approach to antiviral drug discovery', Drug Discovery Today, vol. 6, no. 12, pp. 621-627. https://doi.org/10.1016/S1359-6446(01)01808-6
Frueh, Klaus ; Simmen, Kenneth ; Luukkonen, B. G Mattias ; Bell, Yolanda C. ; Ghazal, Peter. / Virogenomics : A novel approach to antiviral drug discovery. In: Drug Discovery Today. 2001 ; Vol. 6, No. 12. pp. 621-627.
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