TY - JOUR
T1 - Viral modulators of cullin RING ubiquitin ligases
T2 - culling the host defense.
AU - Barry, Michele
AU - Früh, Klaus
PY - 2006/5/16
Y1 - 2006/5/16
N2 - Cullin RING ubiquitin ligases (CRULs) are found in all eukaryotes and play an essential role in targeting proteins for ubiquitin-mediated destruction, thus regulating a plethora of cellular processes. Viruses manipulate CRULs by redirecting this destruction machinery to eliminate unwanted host cell proteins, thus allowing viruses to slip past host immune barriers. Depending on the host organism, virus-modified CRULs can perform an amazing range of tasks, including the elimination of crucial signal transduction molecules in the human interferon pathway and suppression of virus-induced gene silencing in plants. This Perspective summarizes recent advances in our understanding of how viral proteins manipulate the function of CRULs.
AB - Cullin RING ubiquitin ligases (CRULs) are found in all eukaryotes and play an essential role in targeting proteins for ubiquitin-mediated destruction, thus regulating a plethora of cellular processes. Viruses manipulate CRULs by redirecting this destruction machinery to eliminate unwanted host cell proteins, thus allowing viruses to slip past host immune barriers. Depending on the host organism, virus-modified CRULs can perform an amazing range of tasks, including the elimination of crucial signal transduction molecules in the human interferon pathway and suppression of virus-induced gene silencing in plants. This Perspective summarizes recent advances in our understanding of how viral proteins manipulate the function of CRULs.
UR - http://www.scopus.com/inward/record.url?scp=33744797119&partnerID=8YFLogxK
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U2 - 10.1126/stke.3352006pe21
DO - 10.1126/stke.3352006pe21
M3 - Review article
C2 - 16705129
AN - SCOPUS:33744797119
SN - 1937-9145
VL - 2006
SP - pe21
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 335
ER -