Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD)

B. U. Orzechowska, M. Manoharan, J. Sprague, R. D. Estep, M. K. Axthelm, S. W. Wong

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Rhesus macaques (RM) co-infected with simian immunodeficiency virus (SIV) and rhesus macaque rhadinovirus (RRV) develop abnormal cellular proliferations characterized as extra-nodal lymphoma and retroperitoneal fibromatosis (RF). RRV encodes a viral interleukin-6 (vIL-6), much like Kaposi's sarcoma-associated herpesvirus, and involvement of the viral cytokine was examined in proliferative lesions. Methods: Formalin fixed tissue from RM co-infected with SIV and RRV were analyzed for RRV genomes by in situ hybridization and RRV vIL-6 expression by immunofluorescence analysis. Results: In situ hybridization analysis indicated that RRV is present in both types of lesions. Immunofluorescence analysis of different lymphomas and RF revealed positive staining for vIL-6. Similarly to KS, RF lesion is positive for vimentin, CD117 (c-kit), and smooth muscle actin (SMA) and contains T cell, B cell and monocytes/macrophage infiltrates. Conclusions: Our data support the idea that vIL-6 may be critical to the development and progression of lymphoproliferative disorder in RRV/SIV-infected RM.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalJournal of medical primatology
Volume38
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 1 2009

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Keywords

  • Multi-centric Castleman's disease
  • Neoplasia
  • RRV and SIV

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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