TY - JOUR
T1 - Viral interference with antigen presentation to CD8+ T cells
T2 - Lessons from cytomegalovirus
AU - Pinto, Amelia K.
AU - Hill, Ann B.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.
AB - Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.
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U2 - 10.1089/vim.2005.18.434
DO - 10.1089/vim.2005.18.434
M3 - Review article
C2 - 16212522
AN - SCOPUS:32944456222
VL - 18
SP - 434
EP - 444
JO - Viral Immunology
JF - Viral Immunology
SN - 0882-8245
IS - 3
ER -