Viral interference with antigen presentation to CD8+ T cells: Lessons from cytomegalovirus

Amelia K. Pinto, Ann Hill

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.

Original languageEnglish (US)
Pages (from-to)434-444
Number of pages11
JournalViral Immunology
Volume18
Issue number3
DOIs
StatePublished - 2005

Fingerprint

Viral Interference
Antigen Presentation
Cytomegalovirus
Viruses
T-Lymphocytes
Viral Genes
Herpesviridae
Genes

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Viral interference with antigen presentation to CD8+ T cells : Lessons from cytomegalovirus. / Pinto, Amelia K.; Hill, Ann.

In: Viral Immunology, Vol. 18, No. 3, 2005, p. 434-444.

Research output: Contribution to journalArticle

@article{32cfc60653094b85abe010ca0f0cf893,
title = "Viral interference with antigen presentation to CD8+ T cells: Lessons from cytomegalovirus",
abstract = "Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.",
author = "Pinto, {Amelia K.} and Ann Hill",
year = "2005",
doi = "10.1089/vim.2005.18.434",
language = "English (US)",
volume = "18",
pages = "434--444",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

TY - JOUR

T1 - Viral interference with antigen presentation to CD8+ T cells

T2 - Lessons from cytomegalovirus

AU - Pinto, Amelia K.

AU - Hill, Ann

PY - 2005

Y1 - 2005

N2 - Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.

AB - Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that interfere with antigen presentation to CD8+ T cells, although the molecular mechanisms by which this end is achieved differ for human and murine CMVs. In each case, there has been a presumption that these genes are necessary for virus persistence in the host. However, recent data in the murine model casts doubt on that presumption. Here, we review the molecular mechanisms of interference with the class I pathway, and the published data regarding functional significance, with a focus on the murine model.

UR - http://www.scopus.com/inward/record.url?scp=32944456222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32944456222&partnerID=8YFLogxK

U2 - 10.1089/vim.2005.18.434

DO - 10.1089/vim.2005.18.434

M3 - Article

C2 - 16212522

AN - SCOPUS:32944456222

VL - 18

SP - 434

EP - 444

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 3

ER -