Viral inhibition of MHC class II antigen presentation

Nagendra R. Hegde, Mathieu S. Chevalier, David Johnson

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

CD4+ T cells can recognize antigens expressed in virus-infected cells and act cytolytically, to produce antiviral cytokines or to co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms. First, and perhaps foremost, viruses inhibit induction of the expression of MHC class II genes by blocking interferon-γ (IFN-γ) signal transduction and expression of the MHC class II transactivator (CIITA). Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins. It appears that this viral inhibition is designed to prevent presentation of endogenous viral antigens in virus-infected host cells, rather than presentation of exogenous antigens in 'professional' antigen-presenting cells.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalTrends in Immunology
Volume24
Issue number5
DOIs
StatePublished - May 1 2003

Fingerprint

Histocompatibility Antigens Class II
Antigen Presentation
Viruses
Antiviral Agents
T-Lymphocytes
Virus Activation
MHC Class II Genes
Viral Antigens
Antigen-Presenting Cells
Interferons
Signal Transduction
Cytokines
Antigens
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Viral inhibition of MHC class II antigen presentation. / Hegde, Nagendra R.; Chevalier, Mathieu S.; Johnson, David.

In: Trends in Immunology, Vol. 24, No. 5, 01.05.2003, p. 278-285.

Research output: Contribution to journalArticle

Hegde, Nagendra R. ; Chevalier, Mathieu S. ; Johnson, David. / Viral inhibition of MHC class II antigen presentation. In: Trends in Immunology. 2003 ; Vol. 24, No. 5. pp. 278-285.
@article{0db463bc02ef477f8ddef2e0ef5f5424,
title = "Viral inhibition of MHC class II antigen presentation",
abstract = "CD4+ T cells can recognize antigens expressed in virus-infected cells and act cytolytically, to produce antiviral cytokines or to co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms. First, and perhaps foremost, viruses inhibit induction of the expression of MHC class II genes by blocking interferon-γ (IFN-γ) signal transduction and expression of the MHC class II transactivator (CIITA). Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins. It appears that this viral inhibition is designed to prevent presentation of endogenous viral antigens in virus-infected host cells, rather than presentation of exogenous antigens in 'professional' antigen-presenting cells.",
author = "Hegde, {Nagendra R.} and Chevalier, {Mathieu S.} and David Johnson",
year = "2003",
month = "5",
day = "1",
doi = "10.1016/S1471-4906(03)00099-1",
language = "English (US)",
volume = "24",
pages = "278--285",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Viral inhibition of MHC class II antigen presentation

AU - Hegde, Nagendra R.

AU - Chevalier, Mathieu S.

AU - Johnson, David

PY - 2003/5/1

Y1 - 2003/5/1

N2 - CD4+ T cells can recognize antigens expressed in virus-infected cells and act cytolytically, to produce antiviral cytokines or to co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms. First, and perhaps foremost, viruses inhibit induction of the expression of MHC class II genes by blocking interferon-γ (IFN-γ) signal transduction and expression of the MHC class II transactivator (CIITA). Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins. It appears that this viral inhibition is designed to prevent presentation of endogenous viral antigens in virus-infected host cells, rather than presentation of exogenous antigens in 'professional' antigen-presenting cells.

AB - CD4+ T cells can recognize antigens expressed in virus-infected cells and act cytolytically, to produce antiviral cytokines or to co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms. First, and perhaps foremost, viruses inhibit induction of the expression of MHC class II genes by blocking interferon-γ (IFN-γ) signal transduction and expression of the MHC class II transactivator (CIITA). Second, viruses inhibit the MHC class II antigen presentation pathway by affecting the stability or intracellular sorting of class II proteins. It appears that this viral inhibition is designed to prevent presentation of endogenous viral antigens in virus-infected host cells, rather than presentation of exogenous antigens in 'professional' antigen-presenting cells.

UR - http://www.scopus.com/inward/record.url?scp=0038401122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038401122&partnerID=8YFLogxK

U2 - 10.1016/S1471-4906(03)00099-1

DO - 10.1016/S1471-4906(03)00099-1

M3 - Article

VL - 24

SP - 278

EP - 285

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 5

ER -