TY - JOUR
T1 - Viral evasion of T cell immunity
T2 - Ancient mechanisms offering new applications
AU - Horst, Daniëlle
AU - Verweij, Marieke C.
AU - Davison, Andrew J.
AU - Ressing, Maaike E.
AU - Wiertz, Emmanuel J.H.J.
N1 - Funding Information:
We thank Dr. Bryan Griffin for his valuable contributions to this manuscript. We gratefully acknowledge financial support by the Dutch Cancer Foundation (grant RUL 2005-3259 ), the Dutch Diabetes Research Foundation , the Netherlands Scientific Organization (NWO, Vidi 917.76.330 ), and the UK Medical Research Council .
PY - 2011/2
Y1 - 2011/2
N2 - Upon infecting a host, viruses are confronted by a coordinated and multi-faceted immune response. Indeed, evolutionary combat between virus and host has contributed signally to the host's development of a formidable innate and adaptive immune defense arsenal, and to the virus' acquisition of effective means to evade it. Cytotoxic T lymphocytes play a key role in the elimination of virus-infected cells, which they detect through recognition of virus-derived peptides displayed at the cell surface in the context of MHC class I molecules. This highly sensitive recognition system is a prime target for immune evasion strategies deployed by many viruses, particularly large DNA viruses such as herpesviruses and poxviruses. Elucidation of the mode of action of the immune evasion proteins encoded by these viruses has not only provided new insights into viral pathogenesis, but has also led to the discovery of hitherto unknown cell biological and immunological phenomena. Moreover, viral immune evasion proteins constitute extremely useful tools to block defined stages of the MHC class I presentation pathway, not only for research purposes, but also for clinical applications.
AB - Upon infecting a host, viruses are confronted by a coordinated and multi-faceted immune response. Indeed, evolutionary combat between virus and host has contributed signally to the host's development of a formidable innate and adaptive immune defense arsenal, and to the virus' acquisition of effective means to evade it. Cytotoxic T lymphocytes play a key role in the elimination of virus-infected cells, which they detect through recognition of virus-derived peptides displayed at the cell surface in the context of MHC class I molecules. This highly sensitive recognition system is a prime target for immune evasion strategies deployed by many viruses, particularly large DNA viruses such as herpesviruses and poxviruses. Elucidation of the mode of action of the immune evasion proteins encoded by these viruses has not only provided new insights into viral pathogenesis, but has also led to the discovery of hitherto unknown cell biological and immunological phenomena. Moreover, viral immune evasion proteins constitute extremely useful tools to block defined stages of the MHC class I presentation pathway, not only for research purposes, but also for clinical applications.
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U2 - 10.1016/j.coi.2010.11.005
DO - 10.1016/j.coi.2010.11.005
M3 - Review article
C2 - 21146386
AN - SCOPUS:79951670705
SN - 0952-7915
VL - 23
SP - 96
EP - 103
JO - Current opinion in immunology
JF - Current opinion in immunology
IS - 1
ER -