Vesicoureteral reflux

Who benefits from correction

James (Christopher) Austin, Christopher S. Cooper

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

There has been an emergence of a therapeutic nihilistic attitude about the surgical treatment of vesicoureteral reflux (VUR). Evidence-based reviews have questioned whether surgical treatment is beneficial for children with VUR. Even the use of prophylactic antibiotics, which have traditionally been the first-line therapy recommended for virtually all patients with VUR, has come under scrutiny after several randomized controlled trials found them to have no effect on decreasing the risk of urinary tract infections (UTIs) in children with VUR. Grade is the strongest predictor of VUR resolution, with high-grade VUR being much less likely to resolve. Other factors that negatively influence resolution include lower bladder volume or pressure at onset of reflux, older age, female sex, bilateral VUR, ureteral duplication, abnormal or scarred kidneys, and bladder dysfunction. These factors can be used, along with grade, in computer models or nomograms to improve the ability to predict spontaneous resolution.

Original languageEnglish (US)
Pages (from-to)243-252
Number of pages10
JournalUrologic Clinics of North America
Volume37
Issue number2
DOIs
StatePublished - May 2010

Fingerprint

Vesico-Ureteral Reflux
Urinary Bladder
Nomograms
Aptitude
Therapeutics
Urinary Tract Infections
Computer Simulation
Randomized Controlled Trials
Anti-Bacterial Agents
Kidney
Pressure

Keywords

  • Dimercaptosuccinic acid
  • Pyelonephritis
  • Urinary tract infections
  • Vesicoureteral reflux

ASJC Scopus subject areas

  • Urology

Cite this

Vesicoureteral reflux : Who benefits from correction. / Austin, James (Christopher); Cooper, Christopher S.

In: Urologic Clinics of North America, Vol. 37, No. 2, 05.2010, p. 243-252.

Research output: Contribution to journalArticle

@article{2128bb34e7f043e79d8b38f5b1ef676c,
title = "Vesicoureteral reflux: Who benefits from correction",
abstract = "There has been an emergence of a therapeutic nihilistic attitude about the surgical treatment of vesicoureteral reflux (VUR). Evidence-based reviews have questioned whether surgical treatment is beneficial for children with VUR. Even the use of prophylactic antibiotics, which have traditionally been the first-line therapy recommended for virtually all patients with VUR, has come under scrutiny after several randomized controlled trials found them to have no effect on decreasing the risk of urinary tract infections (UTIs) in children with VUR. Grade is the strongest predictor of VUR resolution, with high-grade VUR being much less likely to resolve. Other factors that negatively influence resolution include lower bladder volume or pressure at onset of reflux, older age, female sex, bilateral VUR, ureteral duplication, abnormal or scarred kidneys, and bladder dysfunction. These factors can be used, along with grade, in computer models or nomograms to improve the ability to predict spontaneous resolution.",
keywords = "Dimercaptosuccinic acid, Pyelonephritis, Urinary tract infections, Vesicoureteral reflux",
author = "Austin, {James (Christopher)} and Cooper, {Christopher S.}",
year = "2010",
month = "5",
doi = "10.1016/j.ucl.2010.03.012",
language = "English (US)",
volume = "37",
pages = "243--252",
journal = "Urologic Clinics of North America",
issn = "0094-0143",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Vesicoureteral reflux

T2 - Who benefits from correction

AU - Austin, James (Christopher)

AU - Cooper, Christopher S.

PY - 2010/5

Y1 - 2010/5

N2 - There has been an emergence of a therapeutic nihilistic attitude about the surgical treatment of vesicoureteral reflux (VUR). Evidence-based reviews have questioned whether surgical treatment is beneficial for children with VUR. Even the use of prophylactic antibiotics, which have traditionally been the first-line therapy recommended for virtually all patients with VUR, has come under scrutiny after several randomized controlled trials found them to have no effect on decreasing the risk of urinary tract infections (UTIs) in children with VUR. Grade is the strongest predictor of VUR resolution, with high-grade VUR being much less likely to resolve. Other factors that negatively influence resolution include lower bladder volume or pressure at onset of reflux, older age, female sex, bilateral VUR, ureteral duplication, abnormal or scarred kidneys, and bladder dysfunction. These factors can be used, along with grade, in computer models or nomograms to improve the ability to predict spontaneous resolution.

AB - There has been an emergence of a therapeutic nihilistic attitude about the surgical treatment of vesicoureteral reflux (VUR). Evidence-based reviews have questioned whether surgical treatment is beneficial for children with VUR. Even the use of prophylactic antibiotics, which have traditionally been the first-line therapy recommended for virtually all patients with VUR, has come under scrutiny after several randomized controlled trials found them to have no effect on decreasing the risk of urinary tract infections (UTIs) in children with VUR. Grade is the strongest predictor of VUR resolution, with high-grade VUR being much less likely to resolve. Other factors that negatively influence resolution include lower bladder volume or pressure at onset of reflux, older age, female sex, bilateral VUR, ureteral duplication, abnormal or scarred kidneys, and bladder dysfunction. These factors can be used, along with grade, in computer models or nomograms to improve the ability to predict spontaneous resolution.

KW - Dimercaptosuccinic acid

KW - Pyelonephritis

KW - Urinary tract infections

KW - Vesicoureteral reflux

UR - http://www.scopus.com/inward/record.url?scp=77953524483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953524483&partnerID=8YFLogxK

U2 - 10.1016/j.ucl.2010.03.012

DO - 10.1016/j.ucl.2010.03.012

M3 - Article

VL - 37

SP - 243

EP - 252

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

SN - 0094-0143

IS - 2

ER -