Versatile reagents to introduce caged phosphates

Carlo Dinkel, Oliver Wichmann, Carsten Schultz

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Three novel reagents have been prepared to introduce photoactivatable o-nitrobenzyl phosphate esters. The use of fluorenylmethyl and t-butyl protecting groups allowed for a wide range of chemical transformations after phosphorylation. In addition, the use of S-acetylthioethyl and acyloxymethyl groups resulted in photo- and bioactivatable phosphate triesters of phosphatidic acid.

Original languageEnglish (US)
Pages (from-to)1153-1155
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number6
DOIs
StatePublished - Feb 3 2003

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Keywords

  • AMP
  • Bioactivatable
  • Caged compounds
  • Mannose 1-phosphate
  • Membrane-permeant
  • Phosphatidic acid
  • Phosphorylation
  • Photoactivatable

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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