Verhoeff's query

Is vitamin D effective against retinoblastoma?

Daniel Albert, A. M. Saulenas, S. M. Cohen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In 1966, Verhoeff suggested that retinoblastomas might be sensitive to vitamin D because they sometimes undergo calcification and spontaneous regression. In recent years, the antineoplastic effect of vitamin D has been established in vitro and in vivo. This study presents evidence that vitamin D2 inhibits the growth of the human retinoblastoma cell line (Y-79) grown in athymic mice. In mice treated with ergocalciferol, the subcutaneous retinoblastomas were smaller and showed increased tumor necrosis and calcification. Unfortunately, the vitamin D caused significant toxic reactions. Further studies that reduce the toxicity of vitamin D will be needed before its use in children with retinoblastomas can be advocated. To our knowledge, this is the first demonstration of the activity of ergocalciferol against a tumor in vivo and it suggests that ergocalciferol or one of its derivatives may be an effective chemotherapeutic agent against retinoblastomas in humans.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalArchives of ophthalmology
Volume106
Issue number4
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Retinoblastoma
Ergocalciferols
Vitamin D
Poisons
Nude Mice
Antineoplastic Agents
Neoplasms
Necrosis
Cell Line
Growth

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Verhoeff's query : Is vitamin D effective against retinoblastoma? / Albert, Daniel; Saulenas, A. M.; Cohen, S. M.

In: Archives of ophthalmology, Vol. 106, No. 4, 01.01.1988, p. 536-540.

Research output: Contribution to journalArticle

Albert, Daniel ; Saulenas, A. M. ; Cohen, S. M. / Verhoeff's query : Is vitamin D effective against retinoblastoma?. In: Archives of ophthalmology. 1988 ; Vol. 106, No. 4. pp. 536-540.
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