Ventriculocisternal cerebrospinal perfusion in unanesthetized fetal lambs

J. M. Bissonnette, A. R. Hohimer, B. S. Richardson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Methods have been developed for the placement of cannulas in the lateral cerebral ventricle and cisternum magnum of the fetal lamb. Three to seven days after surgery, perfusion of the cerebral ventricular system was carried out in unanesthetized lambs in utero. Artificial cerebrospinal fluid (CSF) was perfused at 123 μl/min for 4-5 h with no change in fetal arterial O2 pressure, CO2 pressure, pH, mean arterial blood pressure, or heart rate. The preparation is suitable for measurements of net formation of fetal central CSF and also for producing changes in the ionic composition of the fetal CSF.

Original languageEnglish (US)
Pages (from-to)880-883
Number of pages4
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Issue number4
StatePublished - 1981

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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