Ventriculocisternal cerebrospinal perfusion in unanesthetized fetal lambs

J. M. Bissonnette; A. R. Hohimer; B. S. Richardson

doi:10.1152/jappl.1981.50.4.880

Ventriculocisternal cerebrospinal perfusion in unanesthetized fetal lambs

J. M. Bissonnette, A. R. Hohimer, B. S. Richardson

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Methods have been developed for the placement of cannulas in the lateral cerebral ventricle and cisternum magnum of the fetal lamb. Three to seven days after surgery, perfusion of the cerebral ventricular system was carried out in unanesthetized lambs in utero. Artificial cerebrospinal fluid (CSF) was perfused at 123 μl/min for 4-5 h with no change in fetal arterial O₂ pressure, CO₂ pressure, pH, mean arterial blood pressure, or heart rate. The preparation is suitable for measurements of net formation of fetal central CSF and also for producing changes in the ionic composition of the fetal CSF.

Original language	English (US)
Pages (from-to)	880-883
Number of pages	4
Journal	Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume	50
Issue number	4
DOIs	https://doi.org/10.1152/jappl.1981.50.4.880
State	Published - 1981

ASJC Scopus subject areas

Physiology
Endocrinology

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10.1152/jappl.1981.50.4.880

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Ventriculocisternal cerebrospinal perfusion in unanesthetized fetal lambs

Abstract

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