Ventricular tachyarrhythmia during pregnancy in women with heart disease: Data from the ROPAC, a registry from the European Society of Cardiology

Ebru Ertekin; Iris M. van Hagen; Amar M. Salam; Titia P.E. Ruys; Mark R. Johnson; Jana Popelova; William A. Parsonage; Zeinab Ashour; Avraham Shotan; José M. Oliver; Gruschen R. Veldtman; Roger Hall; Jolien W. Roos-Hesselink; Roberto Ferrari; Aldo P. Maggioni; Ariane Marelli; Gary Webb; Harald Kaemmerer; Karen Sliwa; Luigi Tavazzi; Joerg Stein; Uri Elkayam; Ulf Thilen; Werner Budts; Panos Vardas; Michel Komajda; Fausto Pinto; Angeles Alonso; David Wood; Nikolaos Maniadakis; Thierry Ferreira; Gérard Gracia; Cécile Laroche; Viviane Missiamenou; Charles Taylor; Marème Konte; Maryna Andarala; Emanuela Fiorucci; Elin Folkesson Lefrancq; Myriam Glémot; Patti Ann McNeill; Caroline Pommier; Myriam Lafay; A. Aquieri; H. Ruda Vega; M. Vázquez Blanco; K. Lust; N. Fagermo; H. Gabriel; E. Donhauser; Z. Gasimov; T. Jahangirov; I. Hasanova; J. De Backer; L. Demulier; M. de Hosson; M. Beckx; M. Moissens; T. Kovacevic-Preradovic; M. Kozic; M. Lovric; C. Vilas Freire; N. Chilingirova; P. Kratunkov; A. R. Montesclaros; E. Beaubien; E. Gordon; L. Walter; C. Lindsay; N. Wahab; Z. Vavera; A. El Nagar; H. H. Ebaid; W. A. El Sayed Makled; N. Taha; A. Dardier; M. Shabaan; Y. Elrakshy; K. Eltamawey; M. Gamal Abd-El Aziz; A. Saad; W. Aboleineen; K. Sorour; M. A.Meguid Mahdy; L. Iserin; M. Ladouceur; S. Cohen; B. Iung; D. Maisuradze; S. Mebus; U. Gembruch; C. Hammerstingl; W. M. Merz; C. Wald; H. Baumgartner; S. Orwat; R. Schmidt; R. Motz; A. Olsson; F. Berger; N. Nagdyman; A. Frogoudaki; M. Anastasiou-Nana; A. Temesvari; D. Kohalmi; H. Balint; B. Merkely; C. Liptai; M. Bowen; M. Cullen; P. Thornton; V. Husarova; A. Blatt; G. Elbaz-Greener; G. Moravsky; Z. Vered; A. Vazan Fuhrmann; S. Goland; P. Festa; L. Ait Ali; G. Sinagra; I. Puggia; B. D.Agata Mottolese; M. G. Carmina; C. Romeo; R. Crepaz; V. Fesslova; A. Azzarelli; D. Baldi; F. Bovenzi; V. Donvito; E. Vasario; T. Todros; K. Niwa; A. Mussagaliyeva; D. Mekebekova; S. Sharipova; R. Zaliunas; R. Jonkaitiene; J. Petrauskaite; L. Gumbiene; S. Jovanova; A. Cassar; M. Caruana; Y. Karamermer; J. M.J. Cornette; A. van Dijk; L. Bellersen; T. Duijnhouwer; C. De Groot; E. P.G. Pieper; C. van Oppen; P. Polak; E. Wajon; L. Wagenaar; M. Estensen; A. Lesniak-Sobelga; P. Podolec; S. Wisniowska-Smialek; A. Trybuch; P. Hoffman; A. Cichocka-Radwan; M. Lelonek; S. Sobczak; U. Faflik; A. Tomaszuk-Kazberuk; J. Przepiesc; M. Gil; K. Plaskota; O. Trojnarska; N. Guerra; L. de Sousa; V. Petrescu; C. Ginghina; R. Jurcut; I. Mircea Coman; I. Ravilevich Gaisin; L. Valeryevna Shilina; N. Sharashkina; O. Tkacheva; D. Ivanov; O. Irtyuga; L. Jovovic; K. Prokselj; M. Kozelj; C. Elliott; L. Galian-Gay; A. Pijuan-Domenech; M. T. Subirana-Domenech; P. Tornos; N. Murga; P. Escribano-Subías; M. J. Ruiz-Cano; J. Delgado-Jiménez; E. Furenas; M. Dellborg; U. Thilén; M. Schwerzmann; J. Bouchardy; T. Rutz; D. Tobler; L. Sarac; O. Batukan Esen; S. Catirli Enar; A. Al Mulla; N. Bazargani; E. Al Hatou; F. Farook; W. Almahmeed; B. Salih; P. Clifford; N. Bowers; J. Kerr; L. Tellett; L. Hudsmith; P. Thompson; S. Thorne; S. Bowater; P. Nihoyannopoulos; R. Curry; L. Freeman; F. Schroeder; R. Wendler; S. Hammond; C. Talluto; D. Murphy; M. G. Perlroth; K. Chintala; P. Gupta; E. Pare; N. Khatri; N. Scott; D. De Faria-Yeh; A. B. Bhatt; S. Tsiaras; M. Gurvitz; C. Otto; J. Botti; J. Ting; W. R. Davidson

doi:10.1016/j.ijcard.2016.06.061

Ventricular tachyarrhythmia during pregnancy in women with heart disease: Data from the ROPAC, a registry from the European Society of Cardiology

Ebru Ertekin, Iris M. van Hagen, Amar M. Salam, Titia P.E. Ruys, Mark R. Johnson, Jana Popelova, William A. Parsonage, Zeinab Ashour, Avraham Shotan, José M. Oliver, Gruschen R. Veldtman, Roger Hall, Jolien W. Roos-Hesselink, Roberto Ferrari, Aldo P. Maggioni, Ariane Marelli, Gary Webb, Harald Kaemmerer, Karen Sliwa, Luigi TavazziJoerg Stein, Uri Elkayam, Ulf Thilen, Werner Budts, Panos Vardas, Michel Komajda, Fausto Pinto, Angeles Alonso, David Wood, Nikolaos Maniadakis, Thierry Ferreira, Gérard Gracia, Cécile Laroche, Viviane Missiamenou, Charles Taylor, Marème Konte, Maryna Andarala, Emanuela Fiorucci, Elin Folkesson Lefrancq, Myriam Glémot, Patti Ann McNeill, Caroline Pommier, Myriam Lafay, A. Aquieri, H. Ruda Vega, M. Vázquez Blanco, K. Lust, N. Fagermo, H. Gabriel, E. Donhauser, Z. Gasimov, T. Jahangirov, I. Hasanova, J. De Backer, L. Demulier, M. de Hosson, M. Beckx, M. Moissens, T. Kovacevic-Preradovic, M. Kozic, M. Lovric, C. Vilas Freire, N. Chilingirova, P. Kratunkov, A. R. Montesclaros, E. Beaubien, E. Gordon, L. Walter, C. Lindsay, N. Wahab, Z. Vavera, A. El Nagar, H. H. Ebaid, W. A. El Sayed Makled, N. Taha, A. Dardier, M. Shabaan, Y. Elrakshy, K. Eltamawey, M. Gamal Abd-El Aziz, A. Saad, W. Aboleineen, K. Sorour, M. A.Meguid Mahdy, L. Iserin, M. Ladouceur, S. Cohen, B. Iung, D. Maisuradze, S. Mebus, U. Gembruch, C. Hammerstingl, W. M. Merz, C. Wald, H. Baumgartner, S. Orwat, R. Schmidt, R. Motz, A. Olsson, F. Berger, N. Nagdyman, A. Frogoudaki, M. Anastasiou-Nana, A. Temesvari, D. Kohalmi, H. Balint, B. Merkely, C. Liptai, M. Bowen, M. Cullen, P. Thornton, V. Husarova, A. Blatt, G. Elbaz-Greener, G. Moravsky, Z. Vered, A. Vazan Fuhrmann, S. Goland, P. Festa, L. Ait Ali, G. Sinagra, I. Puggia, B. D.Agata Mottolese, M. G. Carmina, C. Romeo, R. Crepaz, V. Fesslova, A. Azzarelli, D. Baldi, F. Bovenzi, V. Donvito, E. Vasario, T. Todros, K. Niwa, A. Mussagaliyeva, D. Mekebekova, S. Sharipova, R. Zaliunas, R. Jonkaitiene, J. Petrauskaite, L. Gumbiene, S. Jovanova, A. Cassar, M. Caruana, Y. Karamermer, J. M.J. Cornette, A. van Dijk, L. Bellersen, T. Duijnhouwer, C. De Groot, E. P.G. Pieper, C. van Oppen, P. Polak, E. Wajon, L. Wagenaar, M. Estensen, A. Lesniak-Sobelga, P. Podolec, S. Wisniowska-Smialek, A. Trybuch, P. Hoffman, A. Cichocka-Radwan, M. Lelonek, S. Sobczak, U. Faflik, A. Tomaszuk-Kazberuk, J. Przepiesc, M. Gil, K. Plaskota, O. Trojnarska, N. Guerra, L. de Sousa, V. Petrescu, C. Ginghina, R. Jurcut, I. Mircea Coman, I. Ravilevich Gaisin, L. Valeryevna Shilina, N. Sharashkina, O. Tkacheva, D. Ivanov, O. Irtyuga, L. Jovovic, K. Prokselj, M. Kozelj, C. Elliott, L. Galian-Gay, A. Pijuan-Domenech, M. T. Subirana-Domenech, P. Tornos, N. Murga, P. Escribano-Subías, M. J. Ruiz-Cano, J. Delgado-Jiménez, E. Furenas, M. Dellborg, U. Thilén, M. Schwerzmann, J. Bouchardy, T. Rutz, D. Tobler, L. Sarac, O. Batukan Esen, S. Catirli Enar, A. Al Mulla, N. Bazargani, E. Al Hatou, F. Farook, W. Almahmeed, B. Salih, P. Clifford, N. Bowers, J. Kerr, L. Tellett, L. Hudsmith, P. Thompson, S. Thorne, S. Bowater, P. Nihoyannopoulos, R. Curry, L. Freeman, F. Schroeder, R. Wendler, S. Hammond, C. Talluto, D. Murphy, M. G. Perlroth, K. Chintala, P. Gupta, E. Pare, N. Khatri, N. Scott, D. De Faria-Yeh, A. B. Bhatt, S. Tsiaras, M. Gurvitz, C. Otto, J. Botti, J. Ting, W. R. Davidson

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.

Original language	English (US)
Pages (from-to)	131-136
Number of pages	6
Journal	International Journal of Cardiology
Volume	220
DOIs	https://doi.org/10.1016/j.ijcard.2016.06.061
State	Published - Oct 1 2016

Keywords

Cardiovascular disease
Fetal outcome
Maternal outcome
Pregnancy
Ventricular tachyarrhythmia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.ijcard.2016.06.061

Cite this

Ertekin, E., van Hagen, I. M., Salam, A. M., Ruys, T. P. E., Johnson, M. R., Popelova, J., Parsonage, W. A., Ashour, Z., Shotan, A., Oliver, J. M., Veldtman, G. R., Hall, R., Roos-Hesselink, J. W., Ferrari, R., Maggioni, A. P., Marelli, A., Webb, G., Kaemmerer, H., Sliwa, K., ... Davidson, W. R. (2016). Ventricular tachyarrhythmia during pregnancy in women with heart disease: Data from the ROPAC, a registry from the European Society of Cardiology. International Journal of Cardiology, 220, 131-136. https://doi.org/10.1016/j.ijcard.2016.06.061

Ertekin, E, van Hagen, IM, Salam, AM, Ruys, TPE, Johnson, MR, Popelova, J, Parsonage, WA, Ashour, Z, Shotan, A, Oliver, JM, Veldtman, GR, Hall, R, Roos-Hesselink, JW, Ferrari, R, Maggioni, AP, Marelli, A, Webb, G, Kaemmerer, H, Sliwa, K, Tavazzi, L, Stein, J, Elkayam, U, Thilen, U, Budts, W, Vardas, P, Komajda, M, Pinto, F, Alonso, A, Wood, D, Maniadakis, N, Ferreira, T, Gracia, G, Laroche, C, Missiamenou, V, Taylor, C, Konte, M, Andarala, M, Fiorucci, E, Lefrancq, EF, Glémot, M, McNeill, PA, Pommier, C, Lafay, M, Aquieri, A, Vega, HR, Blanco, MV, Lust, K, Fagermo, N, Gabriel, H, Donhauser, E, Gasimov, Z, Jahangirov, T, Hasanova, I, De Backer, J, Demulier, L, de Hosson, M, Beckx, M, Moissens, M, Kovacevic-Preradovic, T, Kozic, M, Lovric, M, Freire, CV, Chilingirova, N, Kratunkov, P, Montesclaros, AR, Beaubien, E, Gordon, E, Walter, L, Lindsay, C, Wahab, N, Vavera, Z, El Nagar, A, Ebaid, HH, El Sayed Makled, WA, Taha, N, Dardier, A, Shabaan, M, Elrakshy, Y, Eltamawey, K, Abd-El Aziz, MG, Saad, A, Aboleineen, W, Sorour, K, Mahdy, MAM, Iserin, L, Ladouceur, M, Cohen, S, Iung, B, Maisuradze, D, Mebus, S, Gembruch, U, Hammerstingl, C, Merz, WM, Wald, C, Baumgartner, H, Orwat, S, Schmidt, R, Motz, R, Olsson, A, Berger, F, Nagdyman, N, Frogoudaki, A, Anastasiou-Nana, M, Temesvari, A, Kohalmi, D, Balint, H, Merkely, B, Liptai, C, Bowen, M, Cullen, M, Thornton, P, Husarova, V, Blatt, A, Elbaz-Greener, G, Moravsky, G, Vered, Z, Fuhrmann, AV, Goland, S, Festa, P, Ali, LA, Sinagra, G, Puggia, I, Mottolese, BDA, Carmina, MG, Romeo, C, Crepaz, R, Fesslova, V, Azzarelli, A, Baldi, D, Bovenzi, F, Donvito, V, Vasario, E, Todros, T, Niwa, K, Mussagaliyeva, A, Mekebekova, D, Sharipova, S, Zaliunas, R, Jonkaitiene, R, Petrauskaite, J, Gumbiene, L, Jovanova, S, Cassar, A, Caruana, M, Karamermer, Y, Cornette, JMJ, van Dijk, A, Bellersen, L, Duijnhouwer, T, De Groot, C, Pieper, EPG, van Oppen, C, Polak, P, Wajon, E, Wagenaar, L, Estensen, M, Lesniak-Sobelga, A, Podolec, P, Wisniowska-Smialek, S, Trybuch, A, Hoffman, P, Cichocka-Radwan, A, Lelonek, M, Sobczak, S, Faflik, U, Tomaszuk-Kazberuk, A, Przepiesc, J, Gil, M, Plaskota, K, Trojnarska, O, Guerra, N, de Sousa, L, Petrescu, V, Ginghina, C, Jurcut, R, Coman, IM, Gaisin, IR, Shilina, LV, Sharashkina, N, Tkacheva, O, Ivanov, D, Irtyuga, O, Jovovic, L, Prokselj, K, Kozelj, M, Elliott, C, Galian-Gay, L, Pijuan-Domenech, A, Subirana-Domenech, MT, Tornos, P, Murga, N, Escribano-Subías, P, Ruiz-Cano, MJ, Delgado-Jiménez, J, Furenas, E, Dellborg, M, Thilén, U, Schwerzmann, M, Bouchardy, J, Rutz, T, Tobler, D, Sarac, L, Esen, OB, Enar, SC, Al Mulla, A, Bazargani, N, Al Hatou, E, Farook, F, Almahmeed, W, Salih, B, Clifford, P, Bowers, N, Kerr, J, Tellett, L, Hudsmith, L, Thompson, P, Thorne, S, Bowater, S, Nihoyannopoulos, P, Curry, R, Freeman, L, Schroeder, F, Wendler, R, Hammond, S, Talluto, C, Murphy, D, Perlroth, MG, Chintala, K, Gupta, P, Pare, E, Khatri, N, Scott, N, De Faria-Yeh, D, Bhatt, AB, Tsiaras, S, Gurvitz, M, Otto, C, Botti, J, Ting, J & Davidson, WR 2016, 'Ventricular tachyarrhythmia during pregnancy in women with heart disease: Data from the ROPAC, a registry from the European Society of Cardiology', International Journal of Cardiology, vol. 220, pp. 131-136. https://doi.org/10.1016/j.ijcard.2016.06.061

@article{b953142b0ffd4328a40cb0e73ff16743,

title = "Ventricular tachyarrhythmia during pregnancy in women with heart disease: Data from the ROPAC, a registry from the European Society of Cardiology",

abstract = "Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.",

keywords = "Cardiovascular disease, Fetal outcome, Maternal outcome, Pregnancy, Ventricular tachyarrhythmia",

author = "Ebru Ertekin and {van Hagen}, {Iris M.} and Salam, {Amar M.} and Ruys, {Titia P.E.} and Johnson, {Mark R.} and Jana Popelova and Parsonage, {William A.} and Zeinab Ashour and Avraham Shotan and Oliver, {Jos{\'e} M.} and Veldtman, {Gruschen R.} and Roger Hall and Roos-Hesselink, {Jolien W.} and Roberto Ferrari and Maggioni, {Aldo P.} and Ariane Marelli and Gary Webb and Harald Kaemmerer and Karen Sliwa and Luigi Tavazzi and Joerg Stein and Uri Elkayam and Ulf Thilen and Werner Budts and Panos Vardas and Michel Komajda and Fausto Pinto and Angeles Alonso and David Wood and Nikolaos Maniadakis and Thierry Ferreira and G{\'e}rard Gracia and C{\'e}cile Laroche and Viviane Missiamenou and Charles Taylor and Mar{\`e}me Konte and Maryna Andarala and Emanuela Fiorucci and Lefrancq, {Elin Folkesson} and Myriam Gl{\'e}mot and McNeill, {Patti Ann} and Caroline Pommier and Myriam Lafay and A. Aquieri and Vega, {H. Ruda} and Blanco, {M. V{\'a}zquez} and K. Lust and N. Fagermo and H. Gabriel and E. Donhauser and Z. Gasimov and T. Jahangirov and I. Hasanova and {De Backer}, J. and L. Demulier and {de Hosson}, M. and M. Beckx and M. Moissens and T. Kovacevic-Preradovic and M. Kozic and M. Lovric and Freire, {C. Vilas} and N. Chilingirova and P. Kratunkov and Montesclaros, {A. R.} and E. Beaubien and E. Gordon and L. Walter and C. Lindsay and N. Wahab and Z. Vavera and {El Nagar}, A. and Ebaid, {H. H.} and {El Sayed Makled}, {W. A.} and N. Taha and A. Dardier and M. Shabaan and Y. Elrakshy and K. Eltamawey and {Abd-El Aziz}, {M. Gamal} and A. Saad and W. Aboleineen and K. Sorour and Mahdy, {M. A.Meguid} and L. Iserin and M. Ladouceur and S. Cohen and B. Iung and D. Maisuradze and S. Mebus and U. Gembruch and C. Hammerstingl and Merz, {W. M.} and C. Wald and H. Baumgartner and S. Orwat and R. Schmidt and R. Motz and A. Olsson and F. Berger and N. Nagdyman and A. Frogoudaki and M. Anastasiou-Nana and A. Temesvari and D. Kohalmi and H. Balint and B. Merkely and C. Liptai and M. Bowen and M. Cullen and P. Thornton and V. Husarova and A. Blatt and G. Elbaz-Greener and G. Moravsky and Z. Vered and Fuhrmann, {A. Vazan} and S. Goland and P. Festa and Ali, {L. Ait} and G. Sinagra and I. Puggia and Mottolese, {B. D.Agata} and Carmina, {M. G.} and C. Romeo and R. Crepaz and V. Fesslova and A. Azzarelli and D. Baldi and F. Bovenzi and V. Donvito and E. Vasario and T. Todros and K. Niwa and A. Mussagaliyeva and D. Mekebekova and S. Sharipova and R. Zaliunas and R. Jonkaitiene and J. Petrauskaite and L. Gumbiene and S. Jovanova and A. Cassar and M. Caruana and Y. Karamermer and Cornette, {J. M.J.} and {van Dijk}, A. and L. Bellersen and T. Duijnhouwer and {De Groot}, C. and Pieper, {E. P.G.} and {van Oppen}, C. and P. Polak and E. Wajon and L. Wagenaar and M. Estensen and A. Lesniak-Sobelga and P. Podolec and S. Wisniowska-Smialek and A. Trybuch and P. Hoffman and A. Cichocka-Radwan and M. Lelonek and S. Sobczak and U. Faflik and A. Tomaszuk-Kazberuk and J. Przepiesc and M. Gil and K. Plaskota and O. Trojnarska and N. Guerra and {de Sousa}, L. and V. Petrescu and C. Ginghina and R. Jurcut and Coman, {I. Mircea} and Gaisin, {I. Ravilevich} and Shilina, {L. Valeryevna} and N. Sharashkina and O. Tkacheva and D. Ivanov and O. Irtyuga and L. Jovovic and K. Prokselj and M. Kozelj and C. Elliott and L. Galian-Gay and A. Pijuan-Domenech and Subirana-Domenech, {M. T.} and P. Tornos and N. Murga and P. Escribano-Sub{\'i}as and Ruiz-Cano, {M. J.} and J. Delgado-Jim{\'e}nez and E. Furenas and M. Dellborg and U. Thil{\'e}n and M. Schwerzmann and J. Bouchardy and T. Rutz and D. Tobler and L. Sarac and Esen, {O. Batukan} and Enar, {S. Catirli} and {Al Mulla}, A. and N. Bazargani and {Al Hatou}, E. and F. Farook and W. Almahmeed and B. Salih and P. Clifford and N. Bowers and J. Kerr and L. Tellett and L. Hudsmith and P. Thompson and S. Thorne and S. Bowater and P. Nihoyannopoulos and R. Curry and L. Freeman and F. Schroeder and R. Wendler and S. Hammond and C. Talluto and D. Murphy and Perlroth, {M. G.} and K. Chintala and P. Gupta and E. Pare and N. Khatri and N. Scott and {De Faria-Yeh}, D. and Bhatt, {A. B.} and S. Tsiaras and M. Gurvitz and C. Otto and J. Botti and J. Ting and Davidson, {W. R.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.ijcard.2016.06.061",

language = "English (US)",

volume = "220",

pages = "131--136",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Ventricular tachyarrhythmia during pregnancy in women with heart disease

T2 - Data from the ROPAC, a registry from the European Society of Cardiology

AU - Ertekin, Ebru

AU - van Hagen, Iris M.

AU - Salam, Amar M.

AU - Ruys, Titia P.E.

AU - Johnson, Mark R.

AU - Popelova, Jana

AU - Parsonage, William A.

AU - Ashour, Zeinab

AU - Shotan, Avraham

AU - Oliver, José M.

AU - Veldtman, Gruschen R.

AU - Hall, Roger

AU - Roos-Hesselink, Jolien W.

AU - Ferrari, Roberto

AU - Maggioni, Aldo P.

AU - Marelli, Ariane

AU - Webb, Gary

AU - Kaemmerer, Harald

AU - Sliwa, Karen

AU - Tavazzi, Luigi

AU - Stein, Joerg

AU - Elkayam, Uri

AU - Thilen, Ulf

AU - Budts, Werner

AU - Vardas, Panos

AU - Komajda, Michel

AU - Pinto, Fausto

AU - Alonso, Angeles

AU - Wood, David

AU - Maniadakis, Nikolaos

AU - Ferreira, Thierry

AU - Gracia, Gérard

AU - Laroche, Cécile

AU - Missiamenou, Viviane

AU - Taylor, Charles

AU - Konte, Marème

AU - Andarala, Maryna

AU - Fiorucci, Emanuela

AU - Lefrancq, Elin Folkesson

AU - Glémot, Myriam

AU - McNeill, Patti Ann

AU - Pommier, Caroline

AU - Lafay, Myriam

AU - Aquieri, A.

AU - Vega, H. Ruda

AU - Blanco, M. Vázquez

AU - Lust, K.

AU - Fagermo, N.

AU - Gabriel, H.

AU - Donhauser, E.

AU - Gasimov, Z.

AU - Jahangirov, T.

AU - Hasanova, I.

AU - De Backer, J.

AU - Demulier, L.

AU - de Hosson, M.

AU - Beckx, M.

AU - Moissens, M.

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AU - Davidson, W. R.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.

AB - Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.

KW - Cardiovascular disease

KW - Fetal outcome

KW - Maternal outcome

KW - Pregnancy

KW - Ventricular tachyarrhythmia

UR - http://www.scopus.com/inward/record.url?scp=84976871168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976871168&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2016.06.061

DO - 10.1016/j.ijcard.2016.06.061

M3 - Article

C2 - 27376569

AN - SCOPUS:84976871168

VL - 220

SP - 131

EP - 136

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

Ventricular tachyarrhythmia during pregnancy in women with heart disease: Data from the ROPAC, a registry from the European Society of Cardiology

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