Abstract
Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-136 |
| Number of pages | 6 |
| Journal | International Journal of Cardiology |
| Volume | 220 |
| DOIs | |
| State | Published - Oct 1 2016 |
Keywords
- Cardiovascular disease
- Fetal outcome
- Maternal outcome
- Pregnancy
- Ventricular tachyarrhythmia
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Ventricular tachyarrhythmia during pregnancy in women with heart disease : Data from the ROPAC, a registry from the European Society of Cardiology. / Ertekin, Ebru; van Hagen, Iris M.; Salam, Amar M.; Ruys, Titia P.E.; Johnson, Mark R.; Popelova, Jana; Parsonage, William A.; Ashour, Zeinab; Shotan, Avraham; Oliver, José M.; Veldtman, Gruschen R.; Hall, Roger; Roos-Hesselink, Jolien W.; Ferrari, Roberto; Maggioni, Aldo P.; Marelli, Ariane; Webb, Gary; Kaemmerer, Harald; Sliwa, Karen; Tavazzi, Luigi; Stein, Joerg; Elkayam, Uri; Thilen, Ulf; Budts, Werner; Vardas, Panos; Komajda, Michel; Pinto, Fausto; Alonso, Angeles; Wood, David; Maniadakis, Nikolaos; Ferreira, Thierry; Gracia, Gérard; Laroche, Cécile; Missiamenou, Viviane; Taylor, Charles; Konte, Marème; Andarala, Maryna; Fiorucci, Emanuela; Lefrancq, Elin Folkesson; Glémot, Myriam; McNeill, Patti Ann; Pommier, Caroline; Lafay, Myriam; Aquieri, A.; Vega, H. Ruda; Blanco, M. Vázquez; Lust, K.; Fagermo, N.; Gabriel, H.; Donhauser, E.; Gasimov, Z.; Jahangirov, T.; Hasanova, I.; De Backer, J.; Demulier, L.; de Hosson, M.; Beckx, M.; Moissens, M.; Kovacevic-Preradovic, T.; Kozic, M.; Lovric, M.; Freire, C. Vilas; Chilingirova, N.; Kratunkov, P.; Montesclaros, A. R.; Beaubien, E.; Gordon, E.; Walter, L.; Lindsay, C.; Wahab, N.; Vavera, Z.; El Nagar, A.; Ebaid, H. H.; El Sayed Makled, W. A.; Taha, N.; Dardier, A.; Shabaan, M.; Elrakshy, Y.; Eltamawey, K.; Abd-El Aziz, M. Gamal; Saad, A.; Aboleineen, W.; Sorour, K.; Mahdy, M. A.Meguid; Iserin, L.; Ladouceur, M.; Cohen, S.; Iung, B.; Maisuradze, D.; Mebus, S.; Gembruch, U.; Hammerstingl, C.; Merz, W. M.; Wald, C.; Baumgartner, H.; Orwat, S.; Schmidt, R.; Motz, R.; Olsson, A.; Berger, F.; Nagdyman, N.; Frogoudaki, A.; Anastasiou-Nana, M.; Temesvari, A.; Kohalmi, D.; Balint, H.; Merkely, B.; Liptai, C.; Bowen, M.; Cullen, M.; Thornton, P.; Husarova, V.; Blatt, A.; Elbaz-Greener, G.; Moravsky, G.; Vered, Z.; Fuhrmann, A. Vazan; Goland, S.; Festa, P.; Ali, L. Ait; Sinagra, G.; Puggia, I.; Mottolese, B. D.Agata; Carmina, M. G.; Romeo, C.; Crepaz, R.; Fesslova, V.; Azzarelli, A.; Baldi, D.; Bovenzi, F.; Donvito, V.; Vasario, E.; Todros, T.; Niwa, K.; Mussagaliyeva, A.; Mekebekova, D.; Sharipova, S.; Zaliunas, R.; Jonkaitiene, R.; Petrauskaite, J.; Gumbiene, L.; Jovanova, S.; Cassar, A.; Caruana, M.; Karamermer, Y.; Cornette, J. M.J.; van Dijk, A.; Bellersen, L.; Duijnhouwer, T.; De Groot, C.; Pieper, E. P.G.; van Oppen, C.; Polak, P.; Wajon, E.; Wagenaar, L.; Estensen, M.; Lesniak-Sobelga, A.; Podolec, P.; Wisniowska-Smialek, S.; Trybuch, A.; Hoffman, P.; Cichocka-Radwan, A.; Lelonek, M.; Sobczak, S.; Faflik, U.; Tomaszuk-Kazberuk, A.; Przepiesc, J.; Gil, M.; Plaskota, K.; Trojnarska, O.; Guerra, N.; de Sousa, L.; Petrescu, V.; Ginghina, C.; Jurcut, R.; Coman, I. Mircea; Gaisin, I. Ravilevich; Shilina, L. Valeryevna; Sharashkina, N.; Tkacheva, O.; Ivanov, D.; Irtyuga, O.; Jovovic, L.; Prokselj, K.; Kozelj, M.; Elliott, C.; Galian-Gay, L.; Pijuan-Domenech, A.; Subirana-Domenech, M. T.; Tornos, P.; Murga, N.; Escribano-Subías, P.; Ruiz-Cano, M. J.; Delgado-Jiménez, J.; Furenas, E.; Dellborg, M.; Thilén, U.; Schwerzmann, M.; Bouchardy, J.; Rutz, T.; Tobler, D.; Sarac, L.; Esen, O. Batukan; Enar, S. Catirli; Al Mulla, A.; Bazargani, N.; Al Hatou, E.; Farook, F.; Almahmeed, W.; Salih, B.; Clifford, P.; Bowers, N.; Kerr, J.; Tellett, L.; Hudsmith, L.; Thompson, P.; Thorne, S.; Bowater, S.; Nihoyannopoulos, P.; Curry, R.; Freeman, L.; Schroeder, F.; Wendler, R.; Hammond, S.; Talluto, C.; Murphy, D.; Perlroth, M. G.; Chintala, K.; Gupta, P.; Pare, E.; Khatri, N.; Scott, N.; De Faria-Yeh, D.; Bhatt, A. B.; Tsiaras, S.; Gurvitz, M.; Otto, C.; Botti, J.; Ting, J.; Davidson, W. R.
In: International Journal of Cardiology, Vol. 220, 01.10.2016, p. 131-136.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Ventricular tachyarrhythmia during pregnancy in women with heart disease
T2 - Data from the ROPAC, a registry from the European Society of Cardiology
AU - Ertekin, Ebru
AU - van Hagen, Iris M.
AU - Salam, Amar M.
AU - Ruys, Titia P.E.
AU - Johnson, Mark R.
AU - Popelova, Jana
AU - Parsonage, William A.
AU - Ashour, Zeinab
AU - Shotan, Avraham
AU - Oliver, José M.
AU - Veldtman, Gruschen R.
AU - Hall, Roger
AU - Roos-Hesselink, Jolien W.
AU - Ferrari, Roberto
AU - Maggioni, Aldo P.
AU - Marelli, Ariane
AU - Webb, Gary
AU - Kaemmerer, Harald
AU - Sliwa, Karen
AU - Tavazzi, Luigi
AU - Stein, Joerg
AU - Elkayam, Uri
AU - Thilen, Ulf
AU - Budts, Werner
AU - Vardas, Panos
AU - Komajda, Michel
AU - Pinto, Fausto
AU - Alonso, Angeles
AU - Wood, David
AU - Maniadakis, Nikolaos
AU - Ferreira, Thierry
AU - Gracia, Gérard
AU - Laroche, Cécile
AU - Missiamenou, Viviane
AU - Taylor, Charles
AU - Konte, Marème
AU - Andarala, Maryna
AU - Fiorucci, Emanuela
AU - Lefrancq, Elin Folkesson
AU - Glémot, Myriam
AU - McNeill, Patti Ann
AU - Pommier, Caroline
AU - Lafay, Myriam
AU - Aquieri, A.
AU - Vega, H. Ruda
AU - Blanco, M. Vázquez
AU - Lust, K.
AU - Fagermo, N.
AU - Gabriel, H.
AU - Donhauser, E.
AU - Gasimov, Z.
AU - Jahangirov, T.
AU - Hasanova, I.
AU - De Backer, J.
AU - Demulier, L.
AU - de Hosson, M.
AU - Beckx, M.
AU - Moissens, M.
AU - Kovacevic-Preradovic, T.
AU - Kozic, M.
AU - Lovric, M.
AU - Freire, C. Vilas
AU - Chilingirova, N.
AU - Kratunkov, P.
AU - Montesclaros, A. R.
AU - Beaubien, E.
AU - Gordon, E.
AU - Walter, L.
AU - Lindsay, C.
AU - Wahab, N.
AU - Vavera, Z.
AU - El Nagar, A.
AU - Ebaid, H. H.
AU - El Sayed Makled, W. A.
AU - Taha, N.
AU - Dardier, A.
AU - Shabaan, M.
AU - Elrakshy, Y.
AU - Eltamawey, K.
AU - Abd-El Aziz, M. Gamal
AU - Saad, A.
AU - Aboleineen, W.
AU - Sorour, K.
AU - Mahdy, M. A.Meguid
AU - Iserin, L.
AU - Ladouceur, M.
AU - Cohen, S.
AU - Iung, B.
AU - Maisuradze, D.
AU - Mebus, S.
AU - Gembruch, U.
AU - Hammerstingl, C.
AU - Merz, W. M.
AU - Wald, C.
AU - Baumgartner, H.
AU - Orwat, S.
AU - Schmidt, R.
AU - Motz, R.
AU - Olsson, A.
AU - Berger, F.
AU - Nagdyman, N.
AU - Frogoudaki, A.
AU - Anastasiou-Nana, M.
AU - Temesvari, A.
AU - Kohalmi, D.
AU - Balint, H.
AU - Merkely, B.
AU - Liptai, C.
AU - Bowen, M.
AU - Cullen, M.
AU - Thornton, P.
AU - Husarova, V.
AU - Blatt, A.
AU - Elbaz-Greener, G.
AU - Moravsky, G.
AU - Vered, Z.
AU - Fuhrmann, A. Vazan
AU - Goland, S.
AU - Festa, P.
AU - Ali, L. Ait
AU - Sinagra, G.
AU - Puggia, I.
AU - Mottolese, B. D.Agata
AU - Carmina, M. G.
AU - Romeo, C.
AU - Crepaz, R.
AU - Fesslova, V.
AU - Azzarelli, A.
AU - Baldi, D.
AU - Bovenzi, F.
AU - Donvito, V.
AU - Vasario, E.
AU - Todros, T.
AU - Niwa, K.
AU - Mussagaliyeva, A.
AU - Mekebekova, D.
AU - Sharipova, S.
AU - Zaliunas, R.
AU - Jonkaitiene, R.
AU - Petrauskaite, J.
AU - Gumbiene, L.
AU - Jovanova, S.
AU - Cassar, A.
AU - Caruana, M.
AU - Karamermer, Y.
AU - Cornette, J. M.J.
AU - van Dijk, A.
AU - Bellersen, L.
AU - Duijnhouwer, T.
AU - De Groot, C.
AU - Pieper, E. P.G.
AU - van Oppen, C.
AU - Polak, P.
AU - Wajon, E.
AU - Wagenaar, L.
AU - Estensen, M.
AU - Lesniak-Sobelga, A.
AU - Podolec, P.
AU - Wisniowska-Smialek, S.
AU - Trybuch, A.
AU - Hoffman, P.
AU - Cichocka-Radwan, A.
AU - Lelonek, M.
AU - Sobczak, S.
AU - Faflik, U.
AU - Tomaszuk-Kazberuk, A.
AU - Przepiesc, J.
AU - Gil, M.
AU - Plaskota, K.
AU - Trojnarska, O.
AU - Guerra, N.
AU - de Sousa, L.
AU - Petrescu, V.
AU - Ginghina, C.
AU - Jurcut, R.
AU - Coman, I. Mircea
AU - Gaisin, I. Ravilevich
AU - Shilina, L. Valeryevna
AU - Sharashkina, N.
AU - Tkacheva, O.
AU - Ivanov, D.
AU - Irtyuga, O.
AU - Jovovic, L.
AU - Prokselj, K.
AU - Kozelj, M.
AU - Elliott, C.
AU - Galian-Gay, L.
AU - Pijuan-Domenech, A.
AU - Subirana-Domenech, M. T.
AU - Tornos, P.
AU - Murga, N.
AU - Escribano-Subías, P.
AU - Ruiz-Cano, M. J.
AU - Delgado-Jiménez, J.
AU - Furenas, E.
AU - Dellborg, M.
AU - Thilén, U.
AU - Schwerzmann, M.
AU - Bouchardy, J.
AU - Rutz, T.
AU - Tobler, D.
AU - Sarac, L.
AU - Esen, O. Batukan
AU - Enar, S. Catirli
AU - Al Mulla, A.
AU - Bazargani, N.
AU - Al Hatou, E.
AU - Farook, F.
AU - Almahmeed, W.
AU - Salih, B.
AU - Clifford, P.
AU - Bowers, N.
AU - Kerr, J.
AU - Tellett, L.
AU - Hudsmith, L.
AU - Thompson, P.
AU - Thorne, S.
AU - Bowater, S.
AU - Nihoyannopoulos, P.
AU - Curry, R.
AU - Freeman, L.
AU - Schroeder, F.
AU - Wendler, R.
AU - Hammond, S.
AU - Talluto, C.
AU - Murphy, D.
AU - Perlroth, M. G.
AU - Chintala, K.
AU - Gupta, P.
AU - Pare, E.
AU - Khatri, N.
AU - Scott, N.
AU - De Faria-Yeh, D.
AU - Bhatt, A. B.
AU - Tsiaras, S.
AU - Gurvitz, M.
AU - Otto, C.
AU - Botti, J.
AU - Ting, J.
AU - Davidson, W. R.
N1 - Publisher Copyright: © 2016 Elsevier Ireland Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.
AB - Objectives To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. Background VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. Methods and results From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease. Forty-two women (1.4%) developed clinically relevant VTA during pregnancy, which occurred mainly in the third trimester (48%). NYHA class > 1 before pregnancy was an independent predictor for VTA. Heart failure during pregnancy was more common in women with VTA than in women without VTA (24% vs. 12%, p = 0.03) and maternal mortality was respectively 2.4% and 0.3% (p = 0.15). More women with VTA delivered by Cesarean section than women without VTA (68% vs. 47%, p = 0.01). Neonatal death, preterm birth (< 37 weeks), low birthweight (< 2500 g) and Apgar score < 7 occurred more often in women with VTA (4.8% vs. 0.3%, p = 0.01; 36% vs. 16%, p = 0.001; 33% vs. 15%, p = 0.001 and 25% vs. 7.3%, p = 0.001, respectively). Conclusions VTA occurred in 1.4% of pregnant women with cardiovascular disease, mainly in the third trimester, and was associated with heart failure during pregnancy. NYHA class before pregnancy was predictive. VTA during pregnancy had clear impact on fetal outcome.
KW - Cardiovascular disease
KW - Fetal outcome
KW - Maternal outcome
KW - Pregnancy
KW - Ventricular tachyarrhythmia
UR - http://www.scopus.com/inward/record.url?scp=84976871168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976871168&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.06.061
DO - 10.1016/j.ijcard.2016.06.061
M3 - Article
C2 - 27376569
AN - SCOPUS:84976871168
VL - 220
SP - 131
EP - 136
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -