Ventricular strain in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome before and after prenatal aortic valvuloplasty

Tetsuko Ishii, Doff B. McElhinney, David M. Harrild, Edward N. Marcus, David Sahn, Uyen Truong, Wayne Tworetzky

Research output: Contribution to journalArticle

9 Scopus citations


Objective: The impact of prenatal intervention on fetal cardiac function has not been well defined. We assessed standard ventricular function parameters and strain in fetuses with evolving hypoplastic left heart syndrome (HLHS) treated with fetal aortic valvuloplasty (fAVP). Methods: Fetuses with valvar aortic stenosis that underwent fAVP were studied. Echocardiographic images prior to intervention (Pre), within 1 week after fAVP (Post), and at the last prenatal follow-up examination (FU) were analyzed. Left ventricular (LV) circumferential (LVCS) and longitudinal strain (LVLS), right ventricular (RV) longitudinal strain (RVLS), and LV end-diastolic dimension Z-scores (LVIDD-Z) were documented and compared according to postnatal outcome. Results: Among 57 fetuses studied, the postnatal outcome was biventricular in 23 and univentricular in 34. Prior to fAVP, strain was

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalFetal Diagnosis and Therapy
Issue number1
Publication statusPublished - Feb 2014



  • Aortic stenosis
  • Fetal cardiac intervention
  • Hypoplastic left heart syndrome
  • Speckle tracking
  • Strain
  • Velocity vector imaging

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging

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