Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-)

R. A. Juarez, C. Bryan, M. A. Kelly, David Grandy, M. J. Low

    Research output: Contribution to journalArticle

    Abstract

    To clarify the influence of dopamine (DA) on respiratory control we evaluated the response of awake adult mice (D2R -/-, n=9 and +/+, n=10) in a two chamber plethysmograph under normoxic, hypoxic (8%) and hypercapnic (10%) conditions. At baseline there was no difference in frequency, tidal volume or minute ventilation (VE) between D2R -/- and +/+ mice. The biphasic response to hypoxia was preserved in the D2R -/- mice. During hypercapnia ventilation was stimulated to a greater extent in the D2R -/- mice. Hypoxic Ventilatory Response Hypercapnic Ventilatory Response (Graph Presented) Seconds Seconds In summary 1.) DA acting through the D2R does not influence baseline or acute hypoxic ventilation. 2.) D2R activation blunts CO2 sensitivity during acute hypercapnia.

    Original languageEnglish (US)
    JournalFASEB Journal
    Volume12
    Issue number5
    StatePublished - Mar 20 1998

    Fingerprint

    Dopamine D2 Receptors
    dopamine
    Ventilation
    breathing
    receptors
    Dopamine
    mice
    hypercapnia
    Hypercapnia
    Chemical activation
    tidal volume
    mouse DRD2 protein
    Tidal Volume
    hypoxia

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences (miscellaneous)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Biochemistry
    • Cell Biology

    Cite this

    Juarez, R. A., Bryan, C., Kelly, M. A., Grandy, D., & Low, M. J. (1998). Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-). FASEB Journal, 12(5).

    Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-). / Juarez, R. A.; Bryan, C.; Kelly, M. A.; Grandy, David; Low, M. J.

    In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

    Research output: Contribution to journalArticle

    Juarez, RA, Bryan, C, Kelly, MA, Grandy, D & Low, MJ 1998, 'Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-)', FASEB Journal, vol. 12, no. 5.
    Juarez RA, Bryan C, Kelly MA, Grandy D, Low MJ. Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-). FASEB Journal. 1998 Mar 20;12(5).
    Juarez, R. A. ; Bryan, C. ; Kelly, M. A. ; Grandy, David ; Low, M. J. / Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-). In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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