Venous Thromboembolism: A Survey of Oral Anticoagulant Preferences in the Treatment of Challenging Patient Populations

Genevieve Claire Moyer, Bethany Samuelson Bannow, Courtney Thornburg, Rachel Rosovsky, Tzu Fei Wang, Scott Woller, Dianne Thornhill, Lisa Baumann Kreuziger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Venous thromboembolism (VTE) is a highly morbid condition with several available oral anticoagulant treatment options. Numerous studies have been published comparing warfarin to direct oral anticoagulants; however, several populations remain underrepresented in these reports. We surveyed members of The Venous ThromboEmbolism Network U.S. working group regarding their oral anticoagulant preferences for the treatment of VTE in different and challenging populations. In individuals with VTE and no other medical comorbidities, respondents preferred either rivaroxaban (48.7%) or apixaban (48.7%). Apixaban (53.3%) was preferred in elderly individuals with an increased risk of bleeding. Warfarin was preferred in individuals with liver or kidney dysfunction (42% and 47%), altered metabolism (>55%), and antiphospholipid antibody syndrome (84.2%). Low-molecular-weight heparin was preferred in individuals with malignancy (56.6%), followed by edoxaban (23.7%). These findings may help guide clinicians when choosing an anticoagulant in these challenging situations and demonstrate the urgent need for additional study in these groups.

Original languageEnglish (US)
Pages (from-to)209S-216S
JournalClinical and Applied Thrombosis/Hemostasis
Volume24
Issue number9_suppl
DOIs
StatePublished - Dec 1 2018

Keywords

  • anticoagulants
  • deep vein thrombosis
  • factor Xa inhibitors
  • low-molecular-weight heparins
  • lupus inhibitor
  • venous thromboembolism

ASJC Scopus subject areas

  • Hematology

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