Venous hemodynamic changes in lower limb venous disease: The UIP consensus according to scientific evidence

Byung Boong Lee, Andrew N. Nicolaides, Kenneth Myers, Mark Meissner, Evi Kalodiki, Claudio Allegra, Pier Luigi Antignani, Niels Bækgaard, Kirk Beach, Giovanni Belcaro, Stephen Black, Lena Blomgren, Eliete Bouskela, Massimo Cappelli, Joseph Caprini, Patrick Carpentier, Attilio Cavezzi, Sylvain Chastanet, Jan T. Christenson, Demetris ChristopoulosHeather Clarke, Alun Davies, Marianne De Maeseneer, Bo Eklof, Stefano Ermini, Fidel Fernández, Claude Franceschi, Antonios Gasparis, George Geroulakos, Sergio Gianesini, Athanasios Giannoukas, Peter Gloviczki, Ying Huang, Veronica Ibegbuna, Stavros K. Kakkos, Robert Kistner, Tilo Kölbel, Ralph L M Kurstjens, Nicos Labropoulos, James Laredo, Christopher R Latt Imer, Marzia Lugli, Fedor Lurie, Oscar Maleti, Jovan Markovic, Erika Mendoza, Javier L. Monedero, Gregory (Greg) Moneta, Hayley Moore, Nick Morrison, Giovanni Mosti, Olle Nelzén, Alfred Obermayer, Tomohiro Ogawa, Kurosh Parsi, Hugo Part Sch, Fausto Passariello, Michel R. Perrin, Paul Pittaluga, Seshadri Raju, Stefano Ricci, Antonio Rosales, Angelo Scuderi, Carl Erik Slagsvold, Anders Thurin, Tomasz Urbanek, Andre Van Rij, Michael Vasquez, Cees H A Wittens, Paolo Zamboni, Steven Zimmet, Santiago Zubicoa Ezpeleta

    Research output: Contribution to journalArticle

    48 Citations (Scopus)

    Abstract

    There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolved in the latter part of the 20th century have dominated investigation. They have greatly improved our understanding of the anatomical patterns of venous reflux and obstruction. However, they do not provide the physiological basis for understanding the hemodynamics of flow, pressure, compliance and resistance. Hemodynamic investigations appear to provide a better correlation with post-treatment clinical outcome and quality of life than ultrasound findings. There is a far better prospect for understanding the complete picture of the patient's disability and response to management by combining ultrasound with hemodynamic studies. Accordingly, at the instigation of Dr Angelo Scuderi, the Union Internationale de Phlebologie (UIP) executive board commissioned a large number of experts to assess all aspects of management for venous disease by evidence-based principles. These included experts from various member societies including the European Venous Forum (EVF), American Venous Forum (AVF), American College of Phlebology (ACP) and Cardiovascular Disease Educational and Research Trust (CDERT). Their aim was to confirm or dispel long-held hemodynamic principles and to provide a comprehensive review of venous hemodynamic concepts underlying the pathophysiology of lower limb venous disorders, their usefulness for investigating patients and the relevant hemodynamic changes associated with various forms of treatment. Chapter 1 is devoted to basic hemodynamic concepts and normal venous physiology. Chapter 2 presents the mechanism and magnitude of hemodynamic changes in acute deep vein thrombosis indicating their pathophysiological and clinical significance. Chapter 3 describes the hemodynamic changes that occur in different classes of chronic venous disease and their relation to the anatomic extent of disease in the macrocirculation and microcirculation. The next four chapters (Chapters 4-7) describe the hemodynamic changes resulting from treatment by compression using different materials, intermittent compression devices, pharmacological agents and finally surgical or endovenous ablation. Chapter 8 discusses the unique hemodynamic features associated with alternative treatment techniques used by the CHIVA and ASVAL. Chapter 9 describes the hemodynamic effects following treatment to relieve pelvic reflux and obstruction. Finally, Chapter 10 demonstrates that contrary to general belief there is a moderate to good correlation between certain hemodynamic measurements and clinical severity of chronic venous disease. The authors believe that this document will be a timely asset to both clinicians and researchers alike. It is directed towards surgeons and physicians who are anxious to incorporate the conclusions of research into their daily practice. It is also directed to postgraduate trainees, vascular technologists and bioengineers, particularly to help them understand the hemodynamic background to pathophysiology, investigations and treatment of patients with venous disorders. Hopefully it will be a platform for those who would like to embark on new research in the field of venous disease..

    Original languageEnglish (US)
    Pages (from-to)236-352
    Number of pages117
    JournalInternational Angiology
    Volume35
    Issue number3
    StatePublished - Jun 1 2016

    Fingerprint

    Lower Extremity
    Hemodynamics
    Chronic Disease
    Research
    Therapeutics
    Microcirculation
    Disease Management
    Venous Thrombosis
    Compliance
    Blood Vessels
    Cardiovascular Diseases
    Quality of Life
    Research Personnel
    Pharmacology
    Guidelines

    Keywords

    • Association between venous clinical severity and hemodynamic abnormalities
    • Venous disease
    • Venous hemodynamic changes after treatment
    • Venous hemodynamics
    • Venous macrocirculation
    • Venous microcirculation

    ASJC Scopus subject areas

    • Medicine(all)
    • Cardiology and Cardiovascular Medicine

    Cite this

    Lee, B. B., Nicolaides, A. N., Myers, K., Meissner, M., Kalodiki, E., Allegra, C., ... Ezpeleta, S. Z. (2016). Venous hemodynamic changes in lower limb venous disease: The UIP consensus according to scientific evidence. International Angiology, 35(3), 236-352.

    Venous hemodynamic changes in lower limb venous disease : The UIP consensus according to scientific evidence. / Lee, Byung Boong; Nicolaides, Andrew N.; Myers, Kenneth; Meissner, Mark; Kalodiki, Evi; Allegra, Claudio; Antignani, Pier Luigi; Bækgaard, Niels; Beach, Kirk; Belcaro, Giovanni; Black, Stephen; Blomgren, Lena; Bouskela, Eliete; Cappelli, Massimo; Caprini, Joseph; Carpentier, Patrick; Cavezzi, Attilio; Chastanet, Sylvain; Christenson, Jan T.; Christopoulos, Demetris; Clarke, Heather; Davies, Alun; De Maeseneer, Marianne; Eklof, Bo; Ermini, Stefano; Fernández, Fidel; Franceschi, Claude; Gasparis, Antonios; Geroulakos, George; Gianesini, Sergio; Giannoukas, Athanasios; Gloviczki, Peter; Huang, Ying; Ibegbuna, Veronica; Kakkos, Stavros K.; Kistner, Robert; Kölbel, Tilo; Kurstjens, Ralph L M; Labropoulos, Nicos; Laredo, James; Imer, Christopher R Latt; Lugli, Marzia; Lurie, Fedor; Maleti, Oscar; Markovic, Jovan; Mendoza, Erika; Monedero, Javier L.; Moneta, Gregory (Greg); Moore, Hayley; Morrison, Nick; Mosti, Giovanni; Nelzén, Olle; Obermayer, Alfred; Ogawa, Tomohiro; Parsi, Kurosh; Sch, Hugo Part; Passariello, Fausto; Perrin, Michel R.; Pittaluga, Paul; Raju, Seshadri; Ricci, Stefano; Rosales, Antonio; Scuderi, Angelo; Slagsvold, Carl Erik; Thurin, Anders; Urbanek, Tomasz; Rij, Andre Van; Vasquez, Michael; Wittens, Cees H A; Zamboni, Paolo; Zimmet, Steven; Ezpeleta, Santiago Zubicoa.

    In: International Angiology, Vol. 35, No. 3, 01.06.2016, p. 236-352.

    Research output: Contribution to journalArticle

    Lee, BB, Nicolaides, AN, Myers, K, Meissner, M, Kalodiki, E, Allegra, C, Antignani, PL, Bækgaard, N, Beach, K, Belcaro, G, Black, S, Blomgren, L, Bouskela, E, Cappelli, M, Caprini, J, Carpentier, P, Cavezzi, A, Chastanet, S, Christenson, JT, Christopoulos, D, Clarke, H, Davies, A, De Maeseneer, M, Eklof, B, Ermini, S, Fernández, F, Franceschi, C, Gasparis, A, Geroulakos, G, Gianesini, S, Giannoukas, A, Gloviczki, P, Huang, Y, Ibegbuna, V, Kakkos, SK, Kistner, R, Kölbel, T, Kurstjens, RLM, Labropoulos, N, Laredo, J, Imer, CRL, Lugli, M, Lurie, F, Maleti, O, Markovic, J, Mendoza, E, Monedero, JL, Moneta, GG, Moore, H, Morrison, N, Mosti, G, Nelzén, O, Obermayer, A, Ogawa, T, Parsi, K, Sch, HP, Passariello, F, Perrin, MR, Pittaluga, P, Raju, S, Ricci, S, Rosales, A, Scuderi, A, Slagsvold, CE, Thurin, A, Urbanek, T, Rij, AV, Vasquez, M, Wittens, CHA, Zamboni, P, Zimmet, S & Ezpeleta, SZ 2016, 'Venous hemodynamic changes in lower limb venous disease: The UIP consensus according to scientific evidence', International Angiology, vol. 35, no. 3, pp. 236-352.
    Lee BB, Nicolaides AN, Myers K, Meissner M, Kalodiki E, Allegra C et al. Venous hemodynamic changes in lower limb venous disease: The UIP consensus according to scientific evidence. International Angiology. 2016 Jun 1;35(3):236-352.
    Lee, Byung Boong ; Nicolaides, Andrew N. ; Myers, Kenneth ; Meissner, Mark ; Kalodiki, Evi ; Allegra, Claudio ; Antignani, Pier Luigi ; Bækgaard, Niels ; Beach, Kirk ; Belcaro, Giovanni ; Black, Stephen ; Blomgren, Lena ; Bouskela, Eliete ; Cappelli, Massimo ; Caprini, Joseph ; Carpentier, Patrick ; Cavezzi, Attilio ; Chastanet, Sylvain ; Christenson, Jan T. ; Christopoulos, Demetris ; Clarke, Heather ; Davies, Alun ; De Maeseneer, Marianne ; Eklof, Bo ; Ermini, Stefano ; Fernández, Fidel ; Franceschi, Claude ; Gasparis, Antonios ; Geroulakos, George ; Gianesini, Sergio ; Giannoukas, Athanasios ; Gloviczki, Peter ; Huang, Ying ; Ibegbuna, Veronica ; Kakkos, Stavros K. ; Kistner, Robert ; Kölbel, Tilo ; Kurstjens, Ralph L M ; Labropoulos, Nicos ; Laredo, James ; Imer, Christopher R Latt ; Lugli, Marzia ; Lurie, Fedor ; Maleti, Oscar ; Markovic, Jovan ; Mendoza, Erika ; Monedero, Javier L. ; Moneta, Gregory (Greg) ; Moore, Hayley ; Morrison, Nick ; Mosti, Giovanni ; Nelzén, Olle ; Obermayer, Alfred ; Ogawa, Tomohiro ; Parsi, Kurosh ; Sch, Hugo Part ; Passariello, Fausto ; Perrin, Michel R. ; Pittaluga, Paul ; Raju, Seshadri ; Ricci, Stefano ; Rosales, Antonio ; Scuderi, Angelo ; Slagsvold, Carl Erik ; Thurin, Anders ; Urbanek, Tomasz ; Rij, Andre Van ; Vasquez, Michael ; Wittens, Cees H A ; Zamboni, Paolo ; Zimmet, Steven ; Ezpeleta, Santiago Zubicoa. / Venous hemodynamic changes in lower limb venous disease : The UIP consensus according to scientific evidence. In: International Angiology. 2016 ; Vol. 35, No. 3. pp. 236-352.
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    abstract = "There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolved in the latter part of the 20th century have dominated investigation. They have greatly improved our understanding of the anatomical patterns of venous reflux and obstruction. However, they do not provide the physiological basis for understanding the hemodynamics of flow, pressure, compliance and resistance. Hemodynamic investigations appear to provide a better correlation with post-treatment clinical outcome and quality of life than ultrasound findings. There is a far better prospect for understanding the complete picture of the patient's disability and response to management by combining ultrasound with hemodynamic studies. Accordingly, at the instigation of Dr Angelo Scuderi, the Union Internationale de Phlebologie (UIP) executive board commissioned a large number of experts to assess all aspects of management for venous disease by evidence-based principles. These included experts from various member societies including the European Venous Forum (EVF), American Venous Forum (AVF), American College of Phlebology (ACP) and Cardiovascular Disease Educational and Research Trust (CDERT). Their aim was to confirm or dispel long-held hemodynamic principles and to provide a comprehensive review of venous hemodynamic concepts underlying the pathophysiology of lower limb venous disorders, their usefulness for investigating patients and the relevant hemodynamic changes associated with various forms of treatment. Chapter 1 is devoted to basic hemodynamic concepts and normal venous physiology. Chapter 2 presents the mechanism and magnitude of hemodynamic changes in acute deep vein thrombosis indicating their pathophysiological and clinical significance. Chapter 3 describes the hemodynamic changes that occur in different classes of chronic venous disease and their relation to the anatomic extent of disease in the macrocirculation and microcirculation. The next four chapters (Chapters 4-7) describe the hemodynamic changes resulting from treatment by compression using different materials, intermittent compression devices, pharmacological agents and finally surgical or endovenous ablation. Chapter 8 discusses the unique hemodynamic features associated with alternative treatment techniques used by the CHIVA and ASVAL. Chapter 9 describes the hemodynamic effects following treatment to relieve pelvic reflux and obstruction. Finally, Chapter 10 demonstrates that contrary to general belief there is a moderate to good correlation between certain hemodynamic measurements and clinical severity of chronic venous disease. The authors believe that this document will be a timely asset to both clinicians and researchers alike. It is directed towards surgeons and physicians who are anxious to incorporate the conclusions of research into their daily practice. It is also directed to postgraduate trainees, vascular technologists and bioengineers, particularly to help them understand the hemodynamic background to pathophysiology, investigations and treatment of patients with venous disorders. Hopefully it will be a platform for those who would like to embark on new research in the field of venous disease..",
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    T2 - The UIP consensus according to scientific evidence

    AU - Lee, Byung Boong

    AU - Nicolaides, Andrew N.

    AU - Myers, Kenneth

    AU - Meissner, Mark

    AU - Kalodiki, Evi

    AU - Allegra, Claudio

    AU - Antignani, Pier Luigi

    AU - Bækgaard, Niels

    AU - Beach, Kirk

    AU - Belcaro, Giovanni

    AU - Black, Stephen

    AU - Blomgren, Lena

    AU - Bouskela, Eliete

    AU - Cappelli, Massimo

    AU - Caprini, Joseph

    AU - Carpentier, Patrick

    AU - Cavezzi, Attilio

    AU - Chastanet, Sylvain

    AU - Christenson, Jan T.

    AU - Christopoulos, Demetris

    AU - Clarke, Heather

    AU - Davies, Alun

    AU - De Maeseneer, Marianne

    AU - Eklof, Bo

    AU - Ermini, Stefano

    AU - Fernández, Fidel

    AU - Franceschi, Claude

    AU - Gasparis, Antonios

    AU - Geroulakos, George

    AU - Gianesini, Sergio

    AU - Giannoukas, Athanasios

    AU - Gloviczki, Peter

    AU - Huang, Ying

    AU - Ibegbuna, Veronica

    AU - Kakkos, Stavros K.

    AU - Kistner, Robert

    AU - Kölbel, Tilo

    AU - Kurstjens, Ralph L M

    AU - Labropoulos, Nicos

    AU - Laredo, James

    AU - Imer, Christopher R Latt

    AU - Lugli, Marzia

    AU - Lurie, Fedor

    AU - Maleti, Oscar

    AU - Markovic, Jovan

    AU - Mendoza, Erika

    AU - Monedero, Javier L.

    AU - Moneta, Gregory (Greg)

    AU - Moore, Hayley

    AU - Morrison, Nick

    AU - Mosti, Giovanni

    AU - Nelzén, Olle

    AU - Obermayer, Alfred

    AU - Ogawa, Tomohiro

    AU - Parsi, Kurosh

    AU - Sch, Hugo Part

    AU - Passariello, Fausto

    AU - Perrin, Michel R.

    AU - Pittaluga, Paul

    AU - Raju, Seshadri

    AU - Ricci, Stefano

    AU - Rosales, Antonio

    AU - Scuderi, Angelo

    AU - Slagsvold, Carl Erik

    AU - Thurin, Anders

    AU - Urbanek, Tomasz

    AU - Rij, Andre Van

    AU - Vasquez, Michael

    AU - Wittens, Cees H A

    AU - Zamboni, Paolo

    AU - Zimmet, Steven

    AU - Ezpeleta, Santiago Zubicoa

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    AB - There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolved in the latter part of the 20th century have dominated investigation. They have greatly improved our understanding of the anatomical patterns of venous reflux and obstruction. However, they do not provide the physiological basis for understanding the hemodynamics of flow, pressure, compliance and resistance. Hemodynamic investigations appear to provide a better correlation with post-treatment clinical outcome and quality of life than ultrasound findings. There is a far better prospect for understanding the complete picture of the patient's disability and response to management by combining ultrasound with hemodynamic studies. Accordingly, at the instigation of Dr Angelo Scuderi, the Union Internationale de Phlebologie (UIP) executive board commissioned a large number of experts to assess all aspects of management for venous disease by evidence-based principles. These included experts from various member societies including the European Venous Forum (EVF), American Venous Forum (AVF), American College of Phlebology (ACP) and Cardiovascular Disease Educational and Research Trust (CDERT). Their aim was to confirm or dispel long-held hemodynamic principles and to provide a comprehensive review of venous hemodynamic concepts underlying the pathophysiology of lower limb venous disorders, their usefulness for investigating patients and the relevant hemodynamic changes associated with various forms of treatment. Chapter 1 is devoted to basic hemodynamic concepts and normal venous physiology. Chapter 2 presents the mechanism and magnitude of hemodynamic changes in acute deep vein thrombosis indicating their pathophysiological and clinical significance. Chapter 3 describes the hemodynamic changes that occur in different classes of chronic venous disease and their relation to the anatomic extent of disease in the macrocirculation and microcirculation. The next four chapters (Chapters 4-7) describe the hemodynamic changes resulting from treatment by compression using different materials, intermittent compression devices, pharmacological agents and finally surgical or endovenous ablation. Chapter 8 discusses the unique hemodynamic features associated with alternative treatment techniques used by the CHIVA and ASVAL. Chapter 9 describes the hemodynamic effects following treatment to relieve pelvic reflux and obstruction. Finally, Chapter 10 demonstrates that contrary to general belief there is a moderate to good correlation between certain hemodynamic measurements and clinical severity of chronic venous disease. The authors believe that this document will be a timely asset to both clinicians and researchers alike. It is directed towards surgeons and physicians who are anxious to incorporate the conclusions of research into their daily practice. It is also directed to postgraduate trainees, vascular technologists and bioengineers, particularly to help them understand the hemodynamic background to pathophysiology, investigations and treatment of patients with venous disorders. Hopefully it will be a platform for those who would like to embark on new research in the field of venous disease..

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    KW - Venous hemodynamic changes after treatment

    KW - Venous hemodynamics

    KW - Venous macrocirculation

    KW - Venous microcirculation

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