VDAC channels

E. Blachly-Dyson, M. Forte

Research output: Contribution to journalReview article

145 Scopus citations

Abstract

Trafficking of metabolites across the outer mitochondrial membrane is believed to be mediated primarily by the pore-forming voltage-dependent anion channel, VDAC (also known as mitochondrial porin). An expanding body of in vitro studies have strongly suggest that the pore formed by VDAC can be regulated in a number of ways that implicate it as a site for the regulation of mitochondrial function, yet technical limitations have prevented the extension these studies to a relevant cellular context. The goal of this brief review is to summarize recent data that examine the role of VDAC and its regulation in the context not of the isolated protein or organelles but in cells, focusing on the application of genetic strategies in a number of experimental systems.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalIUBMB Life
Volume52
Issue number3-5
DOIs
StatePublished - Sep 1 2001

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Keywords

  • Genetic analysis
  • Mitochondrial channels
  • Outer membrane

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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