Vav proteins regulate the plasma cell program and secretory Ig production

Linda M. Stephenson, Ana V. Miletic, Tracie Kloeppel, Shana Kusin, Wojciech Swat

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Plasma cell (PC) development is initiated following B cell activation and controlled by a B lymphocyte-induced maturation protein (Blimp)-1-dependent program involving the concerted action of several proplasma transcriptional regulators. However, the factors that control Blimp-1 expression remain largely unknown. In this context, mice deficient for all three of the Vav Family of proteins (Vavnull) develop substantial B cell populations, including marginal zone B cells, yet have a virtual absence of serum Igs, indicating that Vav may be specifically required in PC development and Ig production. We show in this study that mature marginal zone B cells from Vavnull mice proliferate following stimulation with TLR ligands but exhibit severe defects in PC differentiation and Ig secretion. Under conditions inducing PC differentiation, Vavnull B cells fail to efficiently induce Blimp-1, X box-binding protein-1, J chain, or secretory Ig μ transcripts but express IFN-regulatory factor-4 at levels similar to wild-type cells. These data indicate a previously unknown role for Vav as an upstream regulator of Blimp-1.

Original languageEnglish (US)
Pages (from-to)8620-8625
Number of pages6
JournalJournal of Immunology
Volume177
Issue number12
DOIs
StatePublished - Dec 15 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Vav proteins regulate the plasma cell program and secretory Ig production'. Together they form a unique fingerprint.

  • Cite this