Vasopressin receptors in the brain, liver and kidney of rats following osmotic stimulation

Rainer Landgraf, Patricia Szot, Daniel M. Dorsa

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The binding site concentration (Bmax) and equilibrium dissociation constant (Kd) for [3H]-arginine vasopressin (AVP) binding sites were measured in limbic brain areas (septum, dorsal hippocampus, amygdala) and liver and kidney of control and osmotically stimulated male Wistar rats. Membrane binding was performed in these five areas 30, 60 and 180 min following intraperitoneal injection of hypertonic saline. This paradigm resulted in no significant change in binding characteristics in the septum, dorsal hippocampus, amygdala and liver from control treated rats. In contrast, the kidney Bmax was significantly reduced 60min following osmotic stimulation, with no effect on affinity. These results also suggest that AVP receptors in the CNS are relatively resistant to regulatory effects of an acute AVP exposure.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalBrain research
Volume544
Issue number2
DOIs
StatePublished - Mar 29 1991

Keywords

  • Kidney
  • Osmotic stimulation
  • Receptor
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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