Vasopressin receptor subtypes in dorsal hindbrain and renal medulla

Lawrence E. Cornett, Daniel M. Dorsa

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We have investigated the ability of a series of synthetic vasopressin analogues and related peptides to compete with (3H)-arginine8 vasopressin for binding sites in rat renal medulla and dorsal hindbrain. In renal medulla, arginine8 vasopressin and deamino arginine8 vasopressin, a selective antidiuretic, were equipotent while two antagonists of the pressor action of arginine vasopressin were less potent. In the dorsal hindbrain, arginine8 vasopressin and the pressor antagonists were more potent than the synthetic antidiuretic. Potency profiles of these and other analogues suggest that the renal medulla and dorsal hindbrain vasopressin receptors represent different subtypes.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalPeptides
Volume6
Issue number1
DOIs
StatePublished - Jan 2 1985

Keywords

  • Kidney
  • Peptide receptors
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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