Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review

Daniel M. Gibbs

doi:10.1016/0306-4530(86)90048-X

Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review

Daniel M. Gibbs

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

Abstract

ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions of CRF, AVP, and OT to the control of ACTH secretion vary with different types of stress. In general, AVP stimulates ACTH secretion in all species studied. OT also stimulates ACTH release in rats but is inhibitory in primates. The involvement of AVP and OT in the control of ACTH secretion may have important implications for physiological and pathological conditions associated with activation of the hypothalamo - hypophysial - adrenal cortical axis.

Original language	English (US)
Pages (from-to)	131-139
Number of pages	9
Journal	Psychoneuroendocrinology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0306-4530(86)90048-X
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

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abstract = "ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions of CRF, AVP, and OT to the control of ACTH secretion vary with different types of stress. In general, AVP stimulates ACTH secretion in all species studied. OT also stimulates ACTH release in rats but is inhibitory in primates. The involvement of AVP and OT in the control of ACTH secretion may have important implications for physiological and pathological conditions associated with activation of the hypothalamo - hypophysial - adrenal cortical axis.",

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AB - ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions of CRF, AVP, and OT to the control of ACTH secretion vary with different types of stress. In general, AVP stimulates ACTH secretion in all species studied. OT also stimulates ACTH release in rats but is inhibitory in primates. The involvement of AVP and OT in the control of ACTH secretion may have important implications for physiological and pathological conditions associated with activation of the hypothalamo - hypophysial - adrenal cortical axis.

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Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review

Abstract

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