Vasopressin and oxytocin

hypothalamic modulators of the stress response: a review

Daniel M. Gibbs

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

ACTH secretion is primarily controlled by hypothalamic secretion of corticotropin releasing factor (CRF) into pituitary portal blood. However arginine vasopressin (AVP) and oxytocin (OT) can modulate the actions of CRF and at times may be important mediators of stress-induced ACTH secretion. The relative contributions of CRF, AVP, and OT to the control of ACTH secretion vary with different types of stress. In general, AVP stimulates ACTH secretion in all species studied. OT also stimulates ACTH release in rats but is inhibitory in primates. The involvement of AVP and OT in the control of ACTH secretion may have important implications for physiological and pathological conditions associated with activation of the hypothalamo - hypophysial - adrenal cortical axis.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalPsychoneuroendocrinology
Volume11
Issue number2
DOIs
StatePublished - 1986

Fingerprint

Oxytocin
Vasopressins
Adrenocorticotropic Hormone
Arginine Vasopressin
Vasotocin
Corticotropin-Releasing Hormone
Primates

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Vasopressin and oxytocin : hypothalamic modulators of the stress response: a review. / Gibbs, Daniel M.

In: Psychoneuroendocrinology, Vol. 11, No. 2, 1986, p. 131-139.

Research output: Contribution to journalArticle

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