Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats

Pavol Sventek, Jin S. Li, Kevin Grove, Christian F. Deschepper, Ernesto L. Schiffrin

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Inhibition of nitric oxide synthase by L-arginine analogues is associated with elevation of blood pressure in rats. Deoxycorticosterone acetate (DOCA)- salt hypertensive rats and DOCA-salt-treated spontaneously hypertensive rats (SHR) overexpress the endothelin-1 gene in blood vessels, and this is associated with severe vascular hypertrophy, whereas SHR do not overexpress endothelin-1 and exhibit limited vascular hypertrophy. In this study malignant hypertension was induced in SHR by chronic administration of the L- arginine analogue N(G)-nitro-L-arginine methyl ester (L-NAME), a potent inhibitor of nitric oxide synthase, to determine whether malignant hypertension would result in endothelin-1 gene overexpression in blood vessels and in greater severity of vascular hypertrophy, as found in malignant DOCA-salt-treated SHR. L-NAME treatment induced malignant hypertension in SHR, with a systolic blood pressure of 246±2 mm Hg, compared with 211±2 mm Hg (P

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalHypertension
Volume27
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

NG-Nitroarginine Methyl Ester
Endothelin-1
Inbred SHR Rats
Blood Vessels
Malignant Hypertension
Desoxycorticosterone
Hypertrophy
Acetates
Salts
Genes
Blood Pressure
Nitric Oxide Synthase
Arginine

Keywords

  • aorta
  • endothelium-derived relaxing factor
  • nitric oxide
  • resistance arteries

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Sventek, P., Li, J. S., Grove, K., Deschepper, C. F., & Schiffrin, E. L. (1996). Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats. Hypertension, 27(1), 49-55.

Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats. / Sventek, Pavol; Li, Jin S.; Grove, Kevin; Deschepper, Christian F.; Schiffrin, Ernesto L.

In: Hypertension, Vol. 27, No. 1, 1996, p. 49-55.

Research output: Contribution to journalArticle

Sventek, P, Li, JS, Grove, K, Deschepper, CF & Schiffrin, EL 1996, 'Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats', Hypertension, vol. 27, no. 1, pp. 49-55.
Sventek, Pavol ; Li, Jin S. ; Grove, Kevin ; Deschepper, Christian F. ; Schiffrin, Ernesto L. / Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats. In: Hypertension. 1996 ; Vol. 27, No. 1. pp. 49-55.
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