Vascular response of the fetal placenta to local occlusion of the maternal placental vasculature

M. K. Stock, D. F. Anderson, T. M. Phernetton, M. K. McLaughlin, J. H. Rankin

    Research output: Contribution to journalArticle

    29 Scopus citations

    Abstract

    Local regulation of fetal placental blood flow was studied in 6 near-term sheep. Maternal blood flow was reduced or eliminated to 6-17% of the placenta by ligation or embolization with non-radioactive microspheres. Maternal and fetal placental blood flows were measured, using radioactively-labelled microspheres, before and after vascular occlusion. The change in fetal placental blood flow was significantly different in the occluded as compared to the non-occluded cotyledons. Occlusion of the maternal placental vasculature was associated with a 40% decline in the adjacent fetal placental flow after 24h. These data support the concept of a local regulatory interaction between fetal and maternal placental circulations wherein fetal placental blood flow is dependent upon the adjacent maternal flow.

    Original languageEnglish (US)
    Pages (from-to)339-346
    Number of pages8
    JournalJournal of Developmental Physiology
    Volume2
    Issue number5
    StatePublished - Dec 1 1980

      Fingerprint

    ASJC Scopus subject areas

    • Developmental Biology
    • Physiology

    Cite this

    Stock, M. K., Anderson, D. F., Phernetton, T. M., McLaughlin, M. K., & Rankin, J. H. (1980). Vascular response of the fetal placenta to local occlusion of the maternal placental vasculature. Journal of Developmental Physiology, 2(5), 339-346.