Vascular pathophysiology in hearing disorders

Dennis Trune, Anh Nguyen-Huynh

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The inner ear vasculature is responsible for maintenance of the blood-labyrinth barrier, transport of systemic hormones for ion homeostasis, and supplying nutrients for metabolic functions. Unfortunately, these blood vessels also expose the ear to circulating inflammatory factors resulting from systemic diseases. Thus, although the inner ear blood vessels are critical for normal function, they also facilitate pathological mechanisms that result in hearing and vestibular dysfunction. Despite these numerous critical roles of inner ear vasculature, little is known of its normal homeostatic functions and how these are compromised in disease. The objective of this review is to discuss the current concepts of vascular biology, how blood vessels naturally respond to circulating inflammatory factors, and how such mechanisms of vascular pathophysiology may cause hearing loss.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalSeminars in Hearing
Volume33
Issue number3
DOIs
StatePublished - 2012

Fingerprint

Hearing Disorders
Blood Vessels
Inner Ear
Hearing Loss
Hearing
Ear
Homeostasis
Maintenance
Hormones
Ions
Food

Keywords

  • blood vessels
  • blood-labyrinth barrier
  • glycocalyx
  • hearing loss
  • immunopathology

ASJC Scopus subject areas

  • Speech and Hearing

Cite this

Vascular pathophysiology in hearing disorders. / Trune, Dennis; Nguyen-Huynh, Anh.

In: Seminars in Hearing, Vol. 33, No. 3, 2012, p. 242-250.

Research output: Contribution to journalArticle

Trune, Dennis ; Nguyen-Huynh, Anh. / Vascular pathophysiology in hearing disorders. In: Seminars in Hearing. 2012 ; Vol. 33, No. 3. pp. 242-250.
@article{222248acd3bd4c97adadfdfa27903638,
title = "Vascular pathophysiology in hearing disorders",
abstract = "The inner ear vasculature is responsible for maintenance of the blood-labyrinth barrier, transport of systemic hormones for ion homeostasis, and supplying nutrients for metabolic functions. Unfortunately, these blood vessels also expose the ear to circulating inflammatory factors resulting from systemic diseases. Thus, although the inner ear blood vessels are critical for normal function, they also facilitate pathological mechanisms that result in hearing and vestibular dysfunction. Despite these numerous critical roles of inner ear vasculature, little is known of its normal homeostatic functions and how these are compromised in disease. The objective of this review is to discuss the current concepts of vascular biology, how blood vessels naturally respond to circulating inflammatory factors, and how such mechanisms of vascular pathophysiology may cause hearing loss.",
keywords = "blood vessels, blood-labyrinth barrier, glycocalyx, hearing loss, immunopathology",
author = "Dennis Trune and Anh Nguyen-Huynh",
year = "2012",
doi = "10.1055/s-0032-1315723",
language = "English (US)",
volume = "33",
pages = "242--250",
journal = "Seminars in Hearing",
issn = "0734-0451",
publisher = "Thieme Medical Publishers",
number = "3",

}

TY - JOUR

T1 - Vascular pathophysiology in hearing disorders

AU - Trune, Dennis

AU - Nguyen-Huynh, Anh

PY - 2012

Y1 - 2012

N2 - The inner ear vasculature is responsible for maintenance of the blood-labyrinth barrier, transport of systemic hormones for ion homeostasis, and supplying nutrients for metabolic functions. Unfortunately, these blood vessels also expose the ear to circulating inflammatory factors resulting from systemic diseases. Thus, although the inner ear blood vessels are critical for normal function, they also facilitate pathological mechanisms that result in hearing and vestibular dysfunction. Despite these numerous critical roles of inner ear vasculature, little is known of its normal homeostatic functions and how these are compromised in disease. The objective of this review is to discuss the current concepts of vascular biology, how blood vessels naturally respond to circulating inflammatory factors, and how such mechanisms of vascular pathophysiology may cause hearing loss.

AB - The inner ear vasculature is responsible for maintenance of the blood-labyrinth barrier, transport of systemic hormones for ion homeostasis, and supplying nutrients for metabolic functions. Unfortunately, these blood vessels also expose the ear to circulating inflammatory factors resulting from systemic diseases. Thus, although the inner ear blood vessels are critical for normal function, they also facilitate pathological mechanisms that result in hearing and vestibular dysfunction. Despite these numerous critical roles of inner ear vasculature, little is known of its normal homeostatic functions and how these are compromised in disease. The objective of this review is to discuss the current concepts of vascular biology, how blood vessels naturally respond to circulating inflammatory factors, and how such mechanisms of vascular pathophysiology may cause hearing loss.

KW - blood vessels

KW - blood-labyrinth barrier

KW - glycocalyx

KW - hearing loss

KW - immunopathology

UR - http://www.scopus.com/inward/record.url?scp=84864411371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864411371&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1315723

DO - 10.1055/s-0032-1315723

M3 - Article

AN - SCOPUS:84864411371

VL - 33

SP - 242

EP - 250

JO - Seminars in Hearing

JF - Seminars in Hearing

SN - 0734-0451

IS - 3

ER -