Vascular Graft Implantation Using a Bilateral End-to-Side Aortoiliac Preclinical Model

Khanh P. Nguyen, Monica T. Hinds, Deirdre E.J. Anderson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Arterial bypass grafts are a standard preclinical model for evaluating physiology and pathophysiology at graft-material interfaces. Implantations of vascular grafts are commonly done as end-to-end grafts in small animal models. Here we detail bilateral end-to-side aortoiliac graft implantation, which requires open surgery and the creation of vascular anastomoses between the graft material and the infrarenal aorta and iliac artery in a nonhuman primate model. In this model, the aortoiliac graft configuration is created using two 4 mm inner diameter vascular grafts (e.g., ePTFE). After exposure and control of the infrarenal aorta and bilateral common iliac arteries and heparinization, the proximal aortic-graft anastomosis is sewn on the lateral wall of the aorta, and subsequently the distal graft-common iliac anastomosis is sewn on the anterior wall of the common iliac artery with one tube graft. Another tube graft is sewn on the contralateral side in the same manner.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages203-215
Number of pages13
DOIs
StatePublished - 2022
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2375
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Anastomosis
  • Biomaterial
  • End-to-side
  • Vascular graft
  • Vascular surgery
  • ePTFE

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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