TY - JOUR
T1 - Variations in serum müllerian inhibiting substance between white, black, and Hispanic women
AU - Seifer, David B.
AU - Golub, Elizabeth T.
AU - Lambert-Messerlian, Geralyn
AU - Benning, Lorie
AU - Anastos, Kathryn
AU - Watts, D. Heather
AU - Cohen, Mardge H.
AU - Karim, Roksana
AU - Young, Mary A.
AU - Minkoff, Howard
AU - Greenblatt, Ruth M.
N1 - Funding Information:
The Women's Interagency HIV Study is funded by the National Institute of Allergy and Infectious Diseases (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590) and by the National Institute of Child Health and Human Development (UO1-HD-32632). The study is cofunded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Funding is also provided by the National Center for Research Resources (MO1-RR-00071, MO1-RR-00079, MO1-RR-00083).
PY - 2009/11
Y1 - 2009/11
N2 - Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.
AB - Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.
KW - Müllerian inhibiting substance
KW - antimüllerian hormone
KW - ethnicity
KW - ovarian reserve
KW - race
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U2 - 10.1016/j.fertnstert.2008.08.110
DO - 10.1016/j.fertnstert.2008.08.110
M3 - Article
C2 - 18930217
AN - SCOPUS:70350749638
SN - 0015-0282
VL - 92
SP - 1674
EP - 1678
JO - Fertility and sterility
JF - Fertility and sterility
IS - 5
ER -