Variation of the Relaxographic "Shutter-Speed" for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape

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135 Scopus citations

Abstract

Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO

Original languageEnglish (US)
Pages (from-to)1151-1169
Number of pages19
JournalMagnetic Resonance in Medicine
Volume50
Issue number6
DOIs
StatePublished - Dec 1 2003

Keywords

  • CR bolus-tracking
  • Intracellular water lifetime
  • Shutter-speed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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