Variation of the Relaxographic "Shutter-Speed" for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape

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Abstract

Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO

Original languageEnglish (US)
Pages (from-to)1151-1169
Number of pages19
JournalMagnetic Resonance in Medicine
Volume50
Issue number6
DOIs
StatePublished - Dec 2003

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Water
Blood Vessels
Pharmacokinetics
Injections

Keywords

  • CR bolus-tracking
  • Intracellular water lifetime
  • Shutter-speed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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title = "Variation of the Relaxographic {"}Shutter-Speed{"} for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape",
abstract = "Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR {"}shutter-speed{"} (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO",
keywords = "CR bolus-tracking, Intracellular water lifetime, Shutter-speed",
author = "Yankeelov, {Thomas E.} and William Rooney and Xin Li and Springer, {Charles Jr}",
year = "2003",
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doi = "10.1002/mrm.10624",
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volume = "50",
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journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
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TY - JOUR

T1 - Variation of the Relaxographic "Shutter-Speed" for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape

AU - Yankeelov, Thomas E.

AU - Rooney, William

AU - Li, Xin

AU - Springer, Charles Jr

PY - 2003/12

Y1 - 2003/12

N2 - Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO

AB - Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T-1) for the equilibrium transcytolemmal water exchange process increases. The quantity T-1 is given by [r1o[CRo] + R 1o0 - R1i| (where r1o and [CRo] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R1o0 and R1i are the extra- and intracellular 1H2O relaxation rate constants, respectively, in the absence of exchange). The increase of T-1 with [CRo] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO

KW - CR bolus-tracking

KW - Intracellular water lifetime

KW - Shutter-speed

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