Variation in the incidence of uterine leiomyoma among premenopausal women by age and race

Lynn Marshall, Donna Spiegelman, Robert L. Barbieri, Marlene B. Goldman, Joann E. Manson, Graham A. Colditz, Walter C. Willett, David J. Hunter

Research output: Contribution to journalArticle

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Abstract

Objective: To quantify the incidence of uterine leiomyoma confirmed by hysterectomy, ultrasound, or pelvic examination according to age and race among premenopausal women. Methods: From September 1989 through May 1993, 95,061 premenopausal nurses age 25-44 with intact uteri and no history of uterine leiomyoma were followed to determine incidence rates of uterine leiomyoma. The self-reported diagnosis was confirmed in 93% of the medical records obtained for a sample of cases. Using pooled logistic regression, we estimated relative risks (RRs) of uterine leiomyoma according to race and examined whether adjustment for other potential risk factors could explain the variation in the race-specific rates. Results: During 327,065 woman- years, 4181 new cases of uterine leiomyoma were reported. The incidence rates increased with age, and the age-standardized rates of ultrasound- or hysterectomy-confirmed diagnoses per 1000 woman-years were 8.9 among white women and 30.6 among black women. After further adjustment for marital status, body mass index, age at first birth, years since last birth, history of infertility, age at first oral contraceptive use, and current alcohol consumption, the rates among black women were significantly greater for diagnoses confirmed by ultrasound or hysterectomy (RR 3.25; 98% confidence interval [CI] 2.71, 3.88) and by hysterectomy (RR 1.82; 95% CI 1.17, 2.82) compared with rates among white women. We observed similar RRs when the cohort was restricted to participants who reported undergoing a screening physical examination within the 2 years before baseline. Conclusion: A higher prevalence of known risk factors did not explain the excess rate of uterine leiomyoma among premenopausal black women.

Original languageEnglish (US)
Pages (from-to)967-973
Number of pages7
JournalObstetrics and Gynecology
Volume90
Issue number6
DOIs
StatePublished - Dec 1997
Externally publishedYes

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Leiomyoma
Incidence
Hysterectomy
Confidence Intervals
Reproductive History
Gynecological Examination
Birth Order
Marital Status
Oral Contraceptives
Alcohol Drinking
Infertility
Physical Examination
Uterus
Medical Records
Body Mass Index
Logistic Models
Nurses

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Marshall, L., Spiegelman, D., Barbieri, R. L., Goldman, M. B., Manson, J. E., Colditz, G. A., ... Hunter, D. J. (1997). Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstetrics and Gynecology, 90(6), 967-973. https://doi.org/10.1016/S0029-7844(97)00534-6

Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. / Marshall, Lynn; Spiegelman, Donna; Barbieri, Robert L.; Goldman, Marlene B.; Manson, Joann E.; Colditz, Graham A.; Willett, Walter C.; Hunter, David J.

In: Obstetrics and Gynecology, Vol. 90, No. 6, 12.1997, p. 967-973.

Research output: Contribution to journalArticle

Marshall, L, Spiegelman, D, Barbieri, RL, Goldman, MB, Manson, JE, Colditz, GA, Willett, WC & Hunter, DJ 1997, 'Variation in the incidence of uterine leiomyoma among premenopausal women by age and race', Obstetrics and Gynecology, vol. 90, no. 6, pp. 967-973. https://doi.org/10.1016/S0029-7844(97)00534-6
Marshall, Lynn ; Spiegelman, Donna ; Barbieri, Robert L. ; Goldman, Marlene B. ; Manson, Joann E. ; Colditz, Graham A. ; Willett, Walter C. ; Hunter, David J. / Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. In: Obstetrics and Gynecology. 1997 ; Vol. 90, No. 6. pp. 967-973.
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abstract = "Objective: To quantify the incidence of uterine leiomyoma confirmed by hysterectomy, ultrasound, or pelvic examination according to age and race among premenopausal women. Methods: From September 1989 through May 1993, 95,061 premenopausal nurses age 25-44 with intact uteri and no history of uterine leiomyoma were followed to determine incidence rates of uterine leiomyoma. The self-reported diagnosis was confirmed in 93{\%} of the medical records obtained for a sample of cases. Using pooled logistic regression, we estimated relative risks (RRs) of uterine leiomyoma according to race and examined whether adjustment for other potential risk factors could explain the variation in the race-specific rates. Results: During 327,065 woman- years, 4181 new cases of uterine leiomyoma were reported. The incidence rates increased with age, and the age-standardized rates of ultrasound- or hysterectomy-confirmed diagnoses per 1000 woman-years were 8.9 among white women and 30.6 among black women. After further adjustment for marital status, body mass index, age at first birth, years since last birth, history of infertility, age at first oral contraceptive use, and current alcohol consumption, the rates among black women were significantly greater for diagnoses confirmed by ultrasound or hysterectomy (RR 3.25; 98{\%} confidence interval [CI] 2.71, 3.88) and by hysterectomy (RR 1.82; 95{\%} CI 1.17, 2.82) compared with rates among white women. We observed similar RRs when the cohort was restricted to participants who reported undergoing a screening physical examination within the 2 years before baseline. Conclusion: A higher prevalence of known risk factors did not explain the excess rate of uterine leiomyoma among premenopausal black women.",
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AU - Colditz, Graham A.

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