Variation in organophosphate pesticide metabolites in urine of children living in agricultural communities

William Lambert, Michael Lasarev, Juan Muniz, Jennifer Scherer, Joan Rothlein, Juanita Santana, Linda McCauley

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Children of migrant farmworkers are at increased risk of exposure to organophosphate pesticides because of "carry-home" transport processes and residential location. Although this at-risk status is generally recognized, few available reports describe the extent of this exposure among agricultural communities. We quantified dialkyl phosphate (DAP) levels in serial samples of urine from 176 children, 2-6 years of age, in three Oregon communities hosting differing agricultural industries: pears, cherries, and fruit berries. Up to three spot samples of urine were collected from children at the beginning, mid-point, and end of their parents' work seasons. The median levels of dimethylthiophosphate (DMTP), the most commonly detected metabolite, was significantly higher in urine samples from children in each of the three agricultural communities (17.5, 19.0, and 41.0 ng/mL) relative to a reference group of children who lived in an urban community and whose parents did not work in agriculture (6.5 ng/mL; Kruskal-Wallis, p <0.001). After controlling for age, sex, and weight, the median level of DMTP in children in the pear community was 1.92 times higher than the level in children of the berry community [95% confidence interval (CI), 1.14-3.23] and 1.75 times higher than the level in children of the cherry community (95% CI, 0.95-3.23). We observed increasing levels of DMTP across the work season only within the berry community. Levels decreased in the cherry community and remained constant in the pear community. Substantial temporal variation within the children followed demonstrates the need for multiple urine samples to most accurately characterize longer term and/or cumulative exposure. The observed variability in urinary DAP levels, between communities and over time, could be attributed to the types and amounts of organophosphate pesticides used, the timing of applications and degradation of residues in the environment, work operations and hygiene practices, the proximity of housing to orchards and fields, or the movement of these working families. Additional studies of variation in pesticide exposure across agricultural regions are needed.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalEnvironmental Health Perspectives
Volume113
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Organophosphates
Metabolites
Pesticides
urine
metabolite
Urine
Phosphates
Orchards
Pyrus
Fruit
Fruits
Agriculture
Degradation
confidence interval
Parents
phosphate
Confidence Intervals
organophosphorus pesticide
residential location
Industry

Keywords

  • Agriculture
  • Children
  • Farmworkers
  • Pesticides

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Variation in organophosphate pesticide metabolites in urine of children living in agricultural communities. / Lambert, William; Lasarev, Michael; Muniz, Juan; Scherer, Jennifer; Rothlein, Joan; Santana, Juanita; McCauley, Linda.

In: Environmental Health Perspectives, Vol. 113, No. 4, 04.2005, p. 504-508.

Research output: Contribution to journalArticle

Lambert, William ; Lasarev, Michael ; Muniz, Juan ; Scherer, Jennifer ; Rothlein, Joan ; Santana, Juanita ; McCauley, Linda. / Variation in organophosphate pesticide metabolites in urine of children living in agricultural communities. In: Environmental Health Perspectives. 2005 ; Vol. 113, No. 4. pp. 504-508.
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