TY - JOUR
T1 - Variation in Antibiotic Susceptibility of Uropathogens by Age Among Ambulatory Pediatric Patients
AU - McGregor, Jessina C.
AU - Quach, Yennie
AU - Bearden, David T.
AU - Smith, David H.
AU - Sharp, Susan E.
AU - Guzman-Cottrill, Judith A.
N1 - Funding Information:
This study was supported by grants from the National Institutes of Health ( KL2RR024141 to J.C.M.) and the American Association of Colleges of Pharmacy (New Investigator Program award to J.C.M.) .
PY - 2014/3
Y1 - 2014/3
N2 - We compared uropathogen antibiotic susceptibility across age groups of ambulatory pediatric patients. For Escherichia coli (n=5,099) and other Gram-negative rods (n=626), significant differences (p<0.05) existed across age groups for ampicillin, cefazolin, and trimethoprim/sulfamethoxazole susceptibility. In E. coli, differences in trimethoprim/sulfamethoxazole susceptibility varied from 79% in children under 2 to 88% in ages 16-18 (p<0.001), while ampicillin susceptibility varied from 30% in children under 2 to 53% in ages 2-5 (p=0.015). Uropathogen susceptibility to common urinary anti-infectives may be lower in the youngest children. Further investigation into these differences is needed to facilitate appropriate and prudent treatment of urinary tract infections.
AB - We compared uropathogen antibiotic susceptibility across age groups of ambulatory pediatric patients. For Escherichia coli (n=5,099) and other Gram-negative rods (n=626), significant differences (p<0.05) existed across age groups for ampicillin, cefazolin, and trimethoprim/sulfamethoxazole susceptibility. In E. coli, differences in trimethoprim/sulfamethoxazole susceptibility varied from 79% in children under 2 to 88% in ages 16-18 (p<0.001), while ampicillin susceptibility varied from 30% in children under 2 to 53% in ages 2-5 (p=0.015). Uropathogen susceptibility to common urinary anti-infectives may be lower in the youngest children. Further investigation into these differences is needed to facilitate appropriate and prudent treatment of urinary tract infections.
KW - Ambulatory care
KW - Antibiotic resistance
KW - Urinary tract infection
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U2 - 10.1016/j.pedn.2013.09.001
DO - 10.1016/j.pedn.2013.09.001
M3 - Article
C2 - 24091131
AN - SCOPUS:84894261303
SN - 0882-5963
VL - 29
SP - 152
EP - 157
JO - Journal of Pediatric Nursing
JF - Journal of Pediatric Nursing
IS - 2
ER -