TY - JOUR
T1 - Variable Plasma Propranolol Levels in Thyrotoxicosis
AU - Rubenfeld, Sheldon
AU - Silverman, Victor E.
AU - Welch, K. M.A.
AU - Mallette, Lawrence E.
AU - Kohler, Peter O.
PY - 1979/2/15
Y1 - 1979/2/15
N2 - PROPRANOLOL has been widely used in the preparation of thyrotoxic patients for operation,1 2 3 in the treatment of thyroid storm,4 5 and as adjunct6 or sole7 therapy in the symptomatic management of hyperthyroid subjects. Several observers, however, have noted that the degree of relief of hyperthyroid symptoms provided by propranolol alone is not sufficient in many patients.8 9 10 Furthermore, propranolol in conventional doses does not necessarily prevent thyroid storm.11 Since plasma propranolol concentrations were not determined in any of these studies, the apparent therapeutic failures may have been the result of inadequate drug levels. We therefore investigated propranolol pharmacokinetics in thyrotoxic subjects. We.
AB - PROPRANOLOL has been widely used in the preparation of thyrotoxic patients for operation,1 2 3 in the treatment of thyroid storm,4 5 and as adjunct6 or sole7 therapy in the symptomatic management of hyperthyroid subjects. Several observers, however, have noted that the degree of relief of hyperthyroid symptoms provided by propranolol alone is not sufficient in many patients.8 9 10 Furthermore, propranolol in conventional doses does not necessarily prevent thyroid storm.11 Since plasma propranolol concentrations were not determined in any of these studies, the apparent therapeutic failures may have been the result of inadequate drug levels. We therefore investigated propranolol pharmacokinetics in thyrotoxic subjects. We.
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U2 - 10.1056/NEJM197902153000707
DO - 10.1056/NEJM197902153000707
M3 - Article
C2 - 759897
AN - SCOPUS:0018394795
SN - 0028-4793
VL - 300
SP - 353
EP - 354
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 7
ER -