Variable efficacy of glucocorticoids in congenital adrenal hyperplasia

J. W. Hansen, D. L. Loriaux

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The suppression of urinary pregnanetriol and 17 ketosteroids during treatment with cortisol, cortisone, prednisone, and dexamethasone in eight patients with congenital adrenal hyperplasia was examined. A large individual variation in response to each agent was observed. In some individuals, cortisone is less effective than its generally accepted potency would indicate. At equivalent glucocorticoid dosage, dexamethasone was twice as effective as the other steroids in suppressing urinary 17 ketosteroids and pregnanetriol. The potency of dexamethasone in suppressing adrenal function was 80 times that of cortisol, about twice its generally accepted potency as a glucocorticoid or anti inflammatory agent.

Original languageEnglish (US)
Pages (from-to)942-947
Number of pages6
JournalPediatrics
Volume57
Issue number6
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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